2023
Unsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging
Williams M, Bednarski B, Pieszko K, Miller R, Kwiecinski J, Shanbhag A, Liang J, Huang C, Sharir T, Dorbala S, Di Carli M, Einstein A, Sinusas A, Miller E, Bateman T, Fish M, Ruddy T, Acampa W, Hauser M, Kaufmann P, Dey D, Berman D, Slomka P. Unsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2656-2668. PMID: 37067586, PMCID: PMC10317876, DOI: 10.1007/s00259-023-06218-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingCause mortalityTotal perfusion deficitArtery diseaseRisk stratificationPerfusion deficitsHigher body mass indexTomography myocardial perfusion imagingMore diabetes mellitusSPECT myocardial perfusion imagingBetter risk stratificationRisk-stratify patientsBody mass indexREFINE SPECT registrySingle photon emissionDiabetes mellitusMass indexExternal cohortStress imagingMyocardial perfusionPatientsRisk phenotypePerfusion imagingImaging characteristics
2022
Unsupervised machine learning improves risk stratification of patients with visual normal SPECT myocardial perfusion imaging assessments
Bednarski B, Williams M, Pieszko K, Miller R, Huang C, Kwiecinski J, Sharir T, Di Carli M, Fish M, Ruddy T, Hasuer T, Miller E, Acampa W, Berman D, Slomka P. Unsupervised machine learning improves risk stratification of patients with visual normal SPECT myocardial perfusion imaging assessments. European Heart Journal 2022, 43: ehac544.300. DOI: 10.1093/eurheartj/ehac544.300.Peer-Reviewed Original ResearchMajor adverse cardiac eventsPeak systolic blood pressureSystolic blood pressureHigh-risk clustersRisk stratificationMyocardial perfusion imagingNormal perfusionHazard ratioBlood pressureCox proportional hazards analysisHigher left ventricular massHigher body mass indexTomography myocardial perfusion imagingNormal clinical assessmentRisk-stratified subgroupsAdverse cardiac eventsPrevalence of diabetesProportional hazards analysisBetter risk stratificationCoronary artery diseaseImproved risk stratificationManagement of patientsKaplan-Meier curvesBody mass indexLeft ventricular mass