2024
Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2
Martin-Lopez E, Brennan B, Mao T, Spence N, Meller S, Han K, Yahiaoui N, Wang C, Iwasaki A, Greer C. Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2. ENeuro 2024, 11: eneuro.0106-24.2024. PMID: 38834299, PMCID: PMC11185043, DOI: 10.1523/eneuro.0106-24.2024.Peer-Reviewed Original ResearchOlfactory bulbOlfactory epitheliumPiriform cortexOlfactory tractOlfactory systemSARS-CoV-2Projection neuronsMyelination defectsOlfactory sensory neuronsLateral olfactory tractLoss of olfactionRespiratory epithelial cellsLamina propria macrophagesSARS-CoV-2 infectionInfected SCDays of infectionIntegrity of myelinOlfactory dysfunctionInfected microgliaSensitive to infectionOlfactory deficitsSensory neuronsSustentacular cellsNasal cavityNeuronal conduction
2017
The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage
Martin-Lopez E, Ishiguro K, Greer CA. The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage. Cerebral Cortex 2017, 29: 1-16. PMID: 29136113, PMCID: PMC7199997, DOI: 10.1093/cercor/bhx291.Peer-Reviewed Original ResearchConceptsLaminar specificityLaminar organizationNeurogenesis/gliogenesisPrimary afferent inputNeurogenic patternPiriform cortexAfferent inputNeurogenic gradientOlfactory bulbLayers IIGlial organizationNeuronal migrationPC progenitorsLaminar developmentCortexFunctional organizationClonal analysisCell lineagesLikely roleEarly developmentPaleocortexAnteriorNeurogenesisSpecificityGliogenesis
2012
Postnatal characterization of cells in the accessory olfactory bulb of wild type and reeler mice
Martín-López E, Corona R, López-Mascaraque L. Postnatal characterization of cells in the accessory olfactory bulb of wild type and reeler mice. Frontiers In Neuroanatomy 2012, 6: 15. PMID: 22661929, PMCID: PMC3357593, DOI: 10.3389/fnana.2012.00015.Peer-Reviewed Original ResearchAccessory olfactory bulbOlfactory bulbReeler miceCell phenotypeAdaptor protein Dab1Early postnatal developmentGranular cell layerOlfactory systemAccessory olfactory systemGlial cell typesMain olfactory systemWT miceReelin deficiencyGlial markersGranular neuronsPostnatal developmentLearning deficitsMiceCell layerFirst relayCell typesEarly embryonic stagesBulbPhenotypeGenetic background
2011
Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages
Martín-López E, Blanchart A, De Carlos JA, López-Mascaraque L. Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages. PLOS ONE 2011, 6: e26673. PMID: 22046330, PMCID: PMC3201967, DOI: 10.1371/journal.pone.0026673.Peer-Reviewed Original ResearchConceptsWild-type miceOlfactory bulb layersEarly postnatal stagesDab1 expressionEarly brain developmentProjection neuronsReeler miceOlfactory bulbType miceBrain developmentPostnatal stagesProtein expressionBulb layersExpression levelsDab1MiceNeuronsReelin effectsPresent studyReelerRELNCritical rolePossible regulationApparent differencesAdaptor protein
2010
Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb)
Blanchart A, Martín‐López E, De Carlos JA, López‐Mascaraque L. Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb). Glia 2010, 59: 278-292. PMID: 21125652, DOI: 10.1002/glia.21100.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBromodeoxyuridineCell MovementCell ProliferationCells, CulturedEmbryo, MammalianFemaleGene Expression Regulation, DevelopmentalGene Transfer TechniquesGreen Fluorescent ProteinsMiceNerve Tissue ProteinsNeurogliaNeuronsOlfactory BulbOlfactory PathwaysPregnancyProsencephalonConceptsMigratory massCell populationsOlfactory axonsDifferent neural cell populationsOlfactory placodeOlfactory Ensheathing CellsCentral nervous systemLater postnatal stagesEmbryonic day 11Glial markersRetroviral injectionCNS neuronsNeural cell populationsGlomerular layerOlfactory nerveOlfactory bulbPeripheral contributionsNervous systemOlfactory epitheliumDifferent cell populationsDay 11Telencephalic vesiclePostnatal stagesInfected cellsOlfactory system