2015
Species-Specific Dynamic Responses of Gut Bacteria to a Mammalian Glycan
Raghavan V, Groisman EA. Species-Specific Dynamic Responses of Gut Bacteria to a Mammalian Glycan. Journal Of Bacteriology 2015, 197: 1538-1548. PMID: 25691527, PMCID: PMC4403648, DOI: 10.1128/jb.00010-15.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacteroidesChondroitin SulfatesGastrointestinal TractGene Expression ProfilingGene Expression Regulation, BacterialMammalsConceptsUtilization genesRelated speciesBacterial speciesBacteroides speciesPolysaccharide utilization genesCase of genesGut bacteriaGut bacterial speciesOrthologous genesCommunity compositionExpression dynamicsMammalian glycansSole carbon sourceRelated microbesBacterial communitiesMicrobial speciesMammalian intestineSame geneStable coexistenceGut microbial compositionDifferential regulationExpression behaviorGenesMicrobial compositionSustained activation
2014
Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium
Raghavan V, Lowe EC, Townsend GE, Bolam DN, Groisman EA. Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium. Molecular Microbiology 2014, 93: 1010-1025. PMID: 25041429, DOI: 10.1111/mmi.12714.Peer-Reviewed Original ResearchMeSH KeywordsBacterial ProteinsBacteroidesChondroitin SulfatesGastrointestinal TractHumansTranscription, GeneticConceptsUtilization genesRate-determining enzymeGut symbiont Bacteroides thetaiotaomicronB. thetaiotaomicronExcess chondroitin sulfateCatabolic genesChondroitin sulfateNutrient availabilityConstitutive expressionBacteroides thetaiotaomicronGenesGut environmentCatabolic rateTranscriptionTransient increaseThetaiotaomicronAnalogous mechanismEnzymeRegulatorExposureTranscripts