2015
Salmonella promotes virulence by repressing cellulose production
Pontes MH, Lee EJ, Choi J, Groisman EA. Salmonella promotes virulence by repressing cellulose production. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 5183-5188. PMID: 25848006, PMCID: PMC4413311, DOI: 10.1073/pnas.1500989112.Peer-Reviewed Original ResearchConceptsCellulose synthesisWild-type phenotypeWild-type virulenceSalmonella enterica serovar TyphimuriumCyclic diguanylateEnterica serovar TyphimuriumPathogen fitnessAbundant organic polymerMgtC geneAcute virulenceAllosteric activatorAbiotic surfacesMgtC mutantInside macrophagesMutantsVirulence determinantsSerovar TyphimuriumVirulenceCellulose productionEnvironmental insultsCellulose levelsBCSAAttenuated mutantsTraitsDiguanylate
1996
Two-component regulatory systems can interact to process multiple environmental signals
Soncini FC, Groisman EA. Two-component regulatory systems can interact to process multiple environmental signals. Journal Of Bacteriology 1996, 178: 6796-6801. PMID: 8955299, PMCID: PMC178578, DOI: 10.1128/jb.178.23.6796-6801.1996.Peer-Reviewed Original ResearchConceptsTwo-component systemPmrA/PmrB systemTwo-component regulatory systemMultiple environmental signalsPhoP/PhoQAcid-mediated activationPmrA proteinPhoQ proteinResponse regulatorTranscriptional regulationEnvironmental signalsEnvironmental cuesTranscriptionLociRegulatory systemVirulence determinantsGenesProteinPathogenic bacteriaPhoPMild acidificationPmrASalmonella typhimuriumBroad spectrumPhoQIdentification of a pathogenicity island required for Salmonella survival in host cells.
Ochman H, Soncini FC, Solomon F, Groisman EA. Identification of a pathogenicity island required for Salmonella survival in host cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7800-7804. PMID: 8755556, PMCID: PMC38828, DOI: 10.1073/pnas.93.15.7800.Peer-Reviewed Original ResearchConceptsPathogenicity islandType III secretion systemSalmonella typhimurium chromosomeWild-type levelsEpithelial cell invasionWild-type strainSPI genesSecretion systemPutative regulatorHost cellsSecretory apparatusCell invasionSecreted proteaseVirulence determinantsSpi(-) mutantsGenesProteinProteaseSalmonella survivalEnteric pathogensMutantsChromosomesIslandsCulture supernatantsForms of flagellin
1995
Regulation of Salmonella Virulence by Two‐Component Regulatory Systems
Groisman E, Heffron F. Regulation of Salmonella Virulence by Two‐Component Regulatory Systems. 1995, 319-332. DOI: 10.1128/9781555818319.ch20.Peer-Reviewed Original ResearchTwo-component systemEnvZ/OmpR systemTwo-component regulatory systemClassical bacterial geneticsIdentification of lociPhoP/PhoQCrucial virulence factorTranscription regulatory factorsOuter membrane porins OmpCTissue culture model systemTranscriptional regulationBacterial geneticsVirulence defectBacterial pathogenesisMicrobial pathogenesisEnvironmental cuesCulture model systemSalmonella virulenceMutant strainRegulatory factorsPorins OmpCS. typhimuriumRegulatory systemVirulence determinantsAdaptive response
1994
The role of the PhoP/PhoQ regulon in Salmonella virulence
Véscovi E, Soncini FC, Groisman EA. The role of the PhoP/PhoQ regulon in Salmonella virulence. Research In Microbiology 1994, 145: 473-480. PMID: 7855434, DOI: 10.1016/0923-2508(94)90096-5.Peer-Reviewed Original Research