2023
Bacteria require phase separation for fitness in the mammalian gut
Krypotou E, Townsend G, Gao X, Tachiyama S, Liu J, Pokorzynski N, Goodman A, Groisman E. Bacteria require phase separation for fitness in the mammalian gut. Science 2023, 379: 1149-1156. PMID: 36927025, PMCID: PMC10148683, DOI: 10.1126/science.abn7229.Peer-Reviewed Original ResearchConceptsMammalian gutTranscription termination factor RhoTermination factor RhoGene regulationTranscription terminationMechanisms bacteriaBacteria interactionsHuman commensalValuable targetBacteriaRhoGut microbiotaFitnessNovel clinical applicationsTherapeutic manipulationGutHuman healthCommensalRegulation
2016
Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho
Kriner MA, Sevostyanova A, Groisman EA. Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho. Trends In Biochemical Sciences 2016, 41: 690-699. PMID: 27325240, PMCID: PMC4967001, DOI: 10.1016/j.tibs.2016.05.012.Peer-Reviewed Original ResearchConceptsRho-dependent terminatorsLeader regionTranscription termination factor RhoTranscription elongation complexTermination factor RhoTranscription termination eventsTranscription of genesRho-dependent terminationRho loading siteElongation complexGene regulationCellular translationBacterial mRNAsRegulatory inputsPhysiological functionsProtein synthesisTermination eventsNovel mechanismTarget specificityMultistep natureRhoLoading siteMultiple signalsTerminatorRecent studies