1993
Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium.
Parra‐Lopez C, Baer MT, Groisman EA. Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium. The EMBO Journal 1993, 12: 4053-4062. PMID: 8223423, PMCID: PMC413698, DOI: 10.1002/j.1460-2075.1993.tb06089.x.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAmino Acid SequenceAnti-Bacterial AgentsATP-Binding Cassette TransportersBase SequenceBiological TransportCloning, MolecularDrug Resistance, MicrobialEnterobacteriaceaeGenes, BacterialMelittenModels, BiologicalMolecular Sequence DataOperonPeptidesProtaminesSalmonella typhimuriumSequence Analysis, DNASequence Homology, Amino AcidConceptsUptake of oligopeptidesSet of genesOpen reading frameMolecular genetic analysisMammalian mdrYeast STE6Wild-type plasmidOperon structurePeriplasmic componentPeptide pheromoneNovel transporterReading frameKb segmentSalmonella typhimuriumGenetic analysisKb mRNASmall cationic peptidesSuccessful pathogenAntimicrobial peptide melittinSequence analysisCassette familyEnteric bacteriaPeptide transportAntimicrobial peptidesCancer cells
1992
Resistance to host antimicrobial peptides is necessary for Salmonella virulence.
Groisman EA, Parra-Lopez C, Salcedo M, Lipps CJ, Heffron F. Resistance to host antimicrobial peptides is necessary for Salmonella virulence. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 11939-11943. PMID: 1465423, PMCID: PMC50673, DOI: 10.1073/pnas.89.24.11939.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBiological EvolutionBlood ProteinsChromosome MappingCytoplasmic GranulesDefensinsGenes, BacterialGenotypeGranulocytesHumansIn Vitro TechniquesMagaininsMiceMutagenesisPeptidesProtaminesSalmonella InfectionsSalmonella typhimuriumXenopus ProteinsConceptsDifferent phenotypic classesTransposon insertion mutantsHost defense strategiesSalmonella virulence genesBacterium Salmonella typhimuriumResistance mechanismsAntimicrobial peptidesDefensin NP-1Antimicrobial peptide protamineInsertion mutantsResistance lociHost antimicrobial peptidesSalmonella virulencePhenotypic classesMutantsSuccessful pathogenDefective lipopolysaccharideAntibacterial peptidesVirulence genesPeptide mastoparanCecropin P1Defense strategiesUbiquitous typeVirulence propertiesGenes