2023
How Bacterial Pathogens Coordinate Appetite with Virulence
Pokorzynski N, Groisman E. How Bacterial Pathogens Coordinate Appetite with Virulence. Microbiology And Molecular Biology Reviews 2023, 87: e00198-22. PMID: 37358444, PMCID: PMC10521370, DOI: 10.1128/mmbr.00198-22.Peer-Reviewed Original ResearchConceptsVirulence factorsTyphoid-like diseaseIntestinal inflammationFacultative intracellular pathogenImmunocompetent humansGut microbiotaPathogenic outcomesUtilization determinantsIntracellular pathogensSpecific nutrientsAntimicrobial agentsInfectionBacterial pathogensSerovar TyphimuriumBacterial virulencePathogensPathogenic traitsAnimal hostsPathwaySuch pathwaysCertain pathwaysMetabolic pathwaysVirulence programInflammationVirulence
2020
Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter
Yeom J, Shao Y, Groisman EA. Small proteins regulate Salmonella survival inside macrophages by controlling degradation of a magnesium transporter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 20235-20243. PMID: 32753384, PMCID: PMC7443967, DOI: 10.1073/pnas.2006116117.Peer-Reviewed Original ResearchConceptsSmall proteinsAmino acid identityFacultative intracellular pathogenTransporter MgtAProtease FtsHMagnesium transportersAcid identityMacrophage proteinRelated transportersSame transcriptPathogen survivalMgtBIntracellular pathogensSerovar TyphimuriumProteinLimitation conditionsHost tissuesMgtROxidative stressTransportersSalmonella survivalSingular exampleFtsHMacrophagesMgtASalmonella expresses foreign genes during infection by degrading their silencer
Choi J, Groisman EA. Salmonella expresses foreign genes during infection by degrading their silencer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 8074-8082. PMID: 32209674, PMCID: PMC7149492, DOI: 10.1073/pnas.1912808117.Peer-Reviewed Original ResearchConceptsForeign genesH-NSForeign DNAHeat-stable nucleoid-structuring (H-NS) proteinH-NS bindingNucleoid structuring proteinGram-negative bacterial speciesFacultative intracellular pathogenPhoP proteinLon proteaseProtease LonRegulatory sequencesVirulence regulatorGene silencingIntramacrophage survivalStructuring proteinBacterial speciesGenesInside macrophagesIntracellular pathogensSerovar TyphimuriumUncovered mechanismProteinVirulence genesDNA
1994
The role of the PhoP/PhoQ regulon in Salmonella virulence
Véscovi E, Soncini FC, Groisman EA. The role of the PhoP/PhoQ regulon in Salmonella virulence. Research In Microbiology 1994, 145: 473-480. PMID: 7855434, DOI: 10.1016/0923-2508(94)90096-5.Peer-Reviewed Original Research
1989
Salmonella typhimurium phoP virulence gene is a transcriptional regulator.
Groisman EA, Chiao E, Lipps CJ, Heffron F. Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 7077-7081. PMID: 2674945, PMCID: PMC297997, DOI: 10.1073/pnas.86.18.7077.Peer-Reviewed Original ResearchConceptsExpression of lociAmino acid sequenceDifferent environmental stimuliFacultative intracellular pathogenGram-negative speciesTranscriptional regulatorsYeast SaccharomycesExtensive homologyDNA sequencesGene productsAcid sequenceHost phagocytic cellsPhosphate availabilityEnvironmental stimuliIntracellular pathogensPhoP genePhoP mutationVirulence genesPhoPGenesLociSequenceSalmonella typhimuriumPhagocytic cellsPhoBA Salmonella Locus that Controls Resistance to Microbicidal Proteins from Phagocytic Cells
Fields P, Groisman E, Heffron F. A Salmonella Locus that Controls Resistance to Microbicidal Proteins from Phagocytic Cells. Science 1989, 243: 1059-1062. PMID: 2646710, DOI: 10.1126/science.2646710.Peer-Reviewed Original ResearchConceptsIntracellular pathogen Salmonella typhimuriumPhagocytic cellsImportant health problemProfessional phagocytic cellsFacultative intracellular pathogenPrimary defense mechanismHealth problemsMicrobicidal mechanismsPathogen Salmonella typhimuriumIntracellular survivalIntracellular pathogensMicrobicidal proteinsDefense mechanismsSalmonella typhimuriumCells