2000
The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri
Moss J, Fisher P, Vick B, Groisman E, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular Microbiology 2000, 2: 443-452. PMID: 11207599, DOI: 10.1046/j.1462-5822.2000.00065.x.Peer-Reviewed Original ResearchConceptsWild-type strainPhoP mutantPhoP/PhoQ systemTwo-component regulatory systemRegulatory protein PhoPHost cell phagosomesPhoP/PhoQKey virulence genesMutant bacteriaEnteric bacteriumPathogen escapeCell phagosomesHost cellsMutantsWild-type ShigellaPolymorphonuclear leucocytesRegulatory systemVirulence genesAntimicrobial moleculesAntimicrobial peptidesPhoPExtreme acidInflammatory responseEpithelial cellsPhagosomes
1994
The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium
Ochman H, Groisman EA. The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium. EXS 1994, 69: 479-493. PMID: 7994120, DOI: 10.1007/978-3-0348-7527-1_27.Peer-Reviewed Original ResearchConceptsSpecies-specific sequencesSalmonella chromosomeEscherichia coliCodon usage patternsOpen reading frameHost epithelial cellsCommon ancestorMap positionPhenotypic charactersReading frameBase compositionHorizontal transferSalmonella typhimuriumMutant strainGenetic differencesEnteric speciesBacterial speciesGenomePoint mutationsPhenotypic characteristicsSpeciesCorresponding regionChromosomesSpecies differencesEpithelial cells
1993
Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.
Groisman EA, Ochman H. Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri. The EMBO Journal 1993, 12: 3779-3787. PMID: 8404849, PMCID: PMC413660, DOI: 10.1002/j.1460-2075.1993.tb06056.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, BacterialAntigens, SurfaceBase SequenceBlotting, SouthernChromosomes, BacterialDNAEpithelial CellsEpitheliumGenes, BacterialGenetic Complementation TestHumansMiceMolecular Sequence DataMultigene FamilyMutationRestriction MappingSalmonella typhimuriumSequence Homology, Amino AcidShigella flexneriTumor Cells, CulturedConceptsEpithelial cellsEnteric pathogen Salmonella typhimuriumHost epithelial cellsSurface antigenSalmonella typhimuriumPathogen Salmonella typhimuriumConstellation of genesInvasion propertiesShigella flexneriVirulence plasmidShigellaVirulence attributesAntigenSalmonellaBacterial entryProtein secretion