2000
Lateral gene transfer and the nature of bacterial innovation
Ochman H, Lawrence J, Groisman E. Lateral gene transfer and the nature of bacterial innovation. Nature 2000, 405: 299-304. PMID: 10830951, DOI: 10.1038/35012500.Peer-Reviewed Original ResearchConceptsLateral gene transferGene transferHorizontal gene transferBacterial innovationDynamic genomeGenetic diversityAcquisition of sequencesGenetic informationLateral transferBacterial speciesPathogenic characterEukaryotesGenomeChromosomesOrganismsSpeciesDNADiversityBacteriaSequenceSubstantial amount
1997
How Salmonella became a pathogen
Groisman E, Ochman H. How Salmonella became a pathogen. Trends In Microbiology 1997, 5: 343-349. PMID: 9294889, DOI: 10.1016/s0966-842x(97)01099-8.Peer-Reviewed Original Research
1996
Identification of a pathogenicity island required for Salmonella survival in host cells.
Ochman H, Soncini FC, Solomon F, Groisman EA. Identification of a pathogenicity island required for Salmonella survival in host cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7800-7804. PMID: 8755556, PMCID: PMC38828, DOI: 10.1073/pnas.93.15.7800.Peer-Reviewed Original ResearchConceptsPathogenicity islandType III secretion systemSalmonella typhimurium chromosomeWild-type levelsEpithelial cell invasionWild-type strainSPI genesSecretion systemPutative regulatorHost cellsSecretory apparatusCell invasionSecreted proteaseVirulence determinantsSpi(-) mutantsGenesProteinProteaseSalmonella survivalEnteric pathogensMutantsChromosomesIslandsCulture supernatantsForms of flagellin
1994
The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium
Ochman H, Groisman EA. The origin and evolution of species differences in Escherichia coli and Salmonella typhimurium. EXS 1994, 69: 479-493. PMID: 7994120, DOI: 10.1007/978-3-0348-7527-1_27.Peer-Reviewed Original ResearchConceptsSpecies-specific sequencesSalmonella chromosomeEscherichia coliCodon usage patternsOpen reading frameHost epithelial cellsCommon ancestorMap positionPhenotypic charactersReading frameBase compositionHorizontal transferSalmonella typhimuriumMutant strainGenetic differencesEnteric speciesBacterial speciesGenomePoint mutationsPhenotypic characteristicsSpeciesCorresponding regionChromosomesSpecies differencesEpithelial cells
1991
Genome mapping and protein coding region identification using bacteriophage Mu
Groisman E, Pagratis N, Casadaban M. Genome mapping and protein coding region identification using bacteriophage Mu. Gene 1991, 99: 1-7. PMID: 1827084, DOI: 10.1016/0378-1119(91)90026-8.Peer-Reviewed Original ResearchConceptsMu-like phagesT7 RNA polymeraseEscherichia coli KRecombinant DNA technologySpecialized promotersBacterial genesGenome mappingRNA polymeraseBacteriophage T7Coli KHost translationBacteriophage MuMu phageDNA technologyMu vectorTransposonGenesPhagesPseudomonas aeruginosaChromosomesTranscriptionPolymerasePromoterOrganismsProtein