Endothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts
Zakharova I, Zhiven’ M, Saaya S, Shevchenko A, Smirnova A, Strunov A, Karpenko A, Pokushalov E, Ivanova L, Makarevich P, Parfyonova Y, Aboian E, Zakian S. Endothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts. Journal Of Translational Medicine 2017, 15: 54. PMID: 28257636, PMCID: PMC5336693, DOI: 10.1186/s12967-017-1156-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Vessel ProsthesisCell DifferentiationCell ProliferationCell SeparationCell SurvivalCells, CulturedChitosanEndothelial CellsHumansMice, SCIDMyocardiumMyocytes, Smooth MuscleNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1PolyestersProsthesis DesignWeibel-Palade BodiesConceptsSmooth muscle cellsRight atrial appendageMuscle cellsCardiac explantsAtrial appendageHuman right atrial appendagesEndothelial cellsHuman cardiac explantsAngiogenic potentialRight ventricular myocardiumAcetylated low-density lipoproteinLow-density lipoproteinSmooth muscle cell culturesReplacement therapyCell replacement therapyPrimary cell culturesImmunodeficient miceVentricular myocardiumAngiogenic cytokinesCell culturesWeibel-Palade bodiesMyosin heavy chainAngiogenic potencySpecific pathologyVascular cells