2001
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar R, Hayday A. Regulation of Cutaneous Malignancy by γδ T Cells. Science 2001, 294: 605-609. PMID: 11567106, DOI: 10.1126/science.1063916.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinogensCell LineCytotoxicity, ImmunologicDimerizationEpidermisEpithelial CellsHistocompatibility Antigens Class IHumansImmunologic SurveillanceLigandsMembrane ProteinsMiceMice, Inbred C57BLMinor Histocompatibility AntigensMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KProtein ConformationProtein FoldingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsT-Lymphocyte SubsetsConceptsT cellsGammadelta cellsLocal T cellsNatural killer cellsΓδ T cellsGammadelta T cellsCytolytic T cellsSkin carcinoma cellsNKG2D engagementMultiple regimensKiller cellsCutaneous malignanciesCutaneous carcinogenesisEpithelial malignanciesRAE-1Human MICAMalignancyCarcinoma cellsSkin cellsCellsNKG2DRegimensMiceEpitheliumCarcinogenesis
2000
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
Herrick C, MacLeod H, Glusac E, Tigelaar R, Bottomly K. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. Journal Of Clinical Investigation 2000, 105: 765-775. PMID: 10727445, PMCID: PMC377464, DOI: 10.1172/jci8624.Peer-Reviewed Original ResearchConceptsTh2 responsesIL-13IL-4Th2-type immune responseIL-4-deficient miceTh2-promoting cytokinesOVA-specific IgG1Bronchoalveolar lavage fluidWild-type miceAllergen encounterTh2 sensitizationAirway challengeTh2 activationAllergen exposureAtopic individualsBAL fluidEnvironmental allergensWT miceLavage fluidPrimary exposureVivo depletionAnatomic sitesImmune responseAnimal modelsMice