Featured Publications
Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience
Gee DG. Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience. American Journal Of Psychiatry 2021, 178: 998-1013. PMID: 34734741, DOI: 10.1176/appi.ajp.2021.21090944.Peer-Reviewed Original ResearchConceptsEarly adversityProtective factorsEffects of adversityOnset of psychopathologyPathways of riskNeurodevelopmental trajectoriesMajor risk factorAdversityMental healthNeurodevelopmental pathwaysEarly environmentPsychopathologySpecific dimensionsIntervention strategiesFuture researchRisk factorsEarly risk identificationTreatment approachesImmense burdenConceptual modelDevelopmental timingResilienceOngoing refinementRiskFactors
2023
Leveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity
Gee D, Cohodes E. Leveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity. Development And Psychopathology 2023, 35: 2168-2185. PMID: 37929292, PMCID: PMC10872788, DOI: 10.1017/s0954579423001128.Peer-Reviewed Original ResearchCorticolimbic circuitryEmotional functioningYouth emotional functioningEmergence of psychopathologyFavorable mental health outcomesMental health outcomesYouth mental healthEmotion regulationDevelopmental neuroscienceLine of researchNeural mechanismsEarly attachmentEmotional learningEarly adversityFoster resilienceStress reactivityAdversitySensitive periodMental healthClinical interventionsResilienceFunctioningClinical implicationsYouthMajor risk factor
2021
Influences of Caregiving on Development: A Sensitive Period for Biological Embedding of Predictability and Safety Cues
Gee DG, Cohodes EM. Influences of Caregiving on Development: A Sensitive Period for Biological Embedding of Predictability and Safety Cues. Current Directions In Psychological Science 2021, 30: 376-383. PMID: 34675455, PMCID: PMC8528226, DOI: 10.1177/09637214211015673.Peer-Reviewed Original ResearchCorticolimbic circuitryEmotional reactivitySensitive periodCaregiver influenceExternal regulationChildren's emotional reactivityEarly sensitive periodPeriod of plasticityEarly life adversitySafety cuesEmotion regulationNeurobiological mechanismsCaregiving experiencesLife adversityIntervention effortsCaregiver behaviorBehavioral developmentAffective behaviorBiological embeddingHuman researchPowerful influenceAdversityCaregiver inputCaregiversCircuitryMigration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy
Cohodes EM, Kribakaran S, Odriozola P, Bakirci S, McCauley S, Hodges HR, Sisk LM, Zacharek SJ, Gee DG. Migration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy. Developmental Psychobiology 2021, 63: e22158. PMID: 34292596, PMCID: PMC8410670, DOI: 10.1002/dev.22158.Peer-Reviewed Original ResearchConceptsMental healthMigration-related traumaEffects of traumaDevelopment of internalizingEarly life adversityEmotion regulationMigrant childrenTransdiagnostic mechanismsTrauma exposureExternalizing symptomatologyTraumatic experiencesRefugee childrenChildren's exposureDevelopmental neurobiologyChildrenYouthInterdisciplinary effortInternalizingTraumaImplicationsAdversityNeurobiologyContext of migrationSymptomatologyLearning
2020
Caregiving influences on emotional learning and regulation: applying a sensitive period model
Gee DG. Caregiving influences on emotional learning and regulation: applying a sensitive period model. Current Opinion In Behavioral Sciences 2020, 36: 177-184. PMID: 33718534, PMCID: PMC7945765, DOI: 10.1016/j.cobeha.2020.11.003.Peer-Reviewed Original ResearchEmotional learningSensitive period modelCorticolimbic circuitrySensitive periodCross-species evidenceExperience-dependent mechanismsEmotional developmentDevelopmental differencesEarly adversityDifferential associationsAdversityLearningConceptual modelDevelopmental timingExperienceSpecific ageAdolescenceCircuitryMaltreatmentChildhoodInfancyAssociationEvidenceCentral roleDifferences
2013
Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL, Telzer EH, Hare TA, Bookheimer SY, Tottenham N. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15638-15643. PMID: 24019460, PMCID: PMC3785723, DOI: 10.1073/pnas.1307893110.Peer-Reviewed Original ResearchConceptsMaternal deprivationAmygdala-mPFC connectivityEarly adversityEarly maternal deprivationAmygdala-prefrontal connectivityMature connectivityRodent modelsReduced anxietyAdolescent phenotypeHormone cortisolEarly developmental emergenceStress-induced modificationsDeprivationComparison childrenConnectivity patternsChildrenDevelopmental emergenceAnxietyPhenotypeInstitutionalized youthAmygdalaAdversityCortisolOntogenetic adaptation