2020
Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI
Lake EMR, Ge X, Shen X, Herman P, Hyder F, Cardin JA, Higley MJ, Scheinost D, Papademetris X, Crair MC, Constable RT. Simultaneous cortex-wide fluorescence Ca2+ imaging and whole-brain fMRI. Nature Methods 2020, 17: 1262-1271. PMID: 33139894, PMCID: PMC7704940, DOI: 10.1038/s41592-020-00984-6.Peer-Reviewed Original ResearchConceptsOptical measurementsBrain functionTransgenic murine modelFunctional magnetic resonance imagingMagnetic resonance imagingFluorescent measuresWhole-brain fMRIMurine modelResonance imagingFluorescence Ca2Human brain functionConnectivity strengthBOLD signalBrain activityWidefieldLow frequencyImagingModalitiesTransfer functionMeasurementsCortex
2019
Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles
Taylor-Giorlando M, Scheinost D, Ment L, Rothman D, Horvath TL. Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles. Cerebral Cortex 2019, 29: 5061-5071. PMID: 30877804, PMCID: PMC6918927, DOI: 10.1093/cercor/bhz046.Peer-Reviewed Original ResearchConceptsMode of deliverySurgical deliveryLayer 3 pyramidal neuronsAlters mitochondrial dynamicsValues of miceMurine findingsCerebral cortexPyramidal neuronsAdult behaviorHuman neonatesMaze testPrepulse inhibitionSpine synapsesPsychiatric illnessAdult miceNeuronal circuitryAnimal modelsClinical relevanceHuman clinical relevanceUCP-2Prefrontal cortexMitochondrial adaptationsImpaired performanceMitochondrial mechanismsBehavioral phenotypes
2012
CT‐PET weighted image fusion for separately scanned whole body rat
Suh JW, Kwon O, Scheinost D, Sinusas AJ, Cline GW, Papademetris X. CT‐PET weighted image fusion for separately scanned whole body rat. Medical Physics 2012, 39: 533-542. PMID: 22225323, PMCID: PMC3266828, DOI: 10.1118/1.3672167.Peer-Reviewed Original ResearchConceptsEmission PET imagesInput imageRegistration processMultimodal registrationRegistration methodMultiple input imagesImage fusion applicationsImage fusion techniqueDistance similarity measureNormalized mutual informationComplementary anatomic informationDeformable registration processCT imagesSeparate scannersInformative imagesPET imagesImage fusionSimilarity measureFusion techniqueHistogram matchingImage setsPositron emission tomography (PET) imagesImage characteristicsNonrigid changesMutual information
2011
Serial monitoring of endogenous neuroblast migration by cellular MRI
Granot D, Scheinost D, Markakis EA, Papademetris X, Shapiro EM. Serial monitoring of endogenous neuroblast migration by cellular MRI. NeuroImage 2011, 57: 817-824. PMID: 21571076, PMCID: PMC3129484, DOI: 10.1016/j.neuroimage.2011.04.063.Peer-Reviewed Original Research
2010
A non-rigid registration method for serial lower extremity hybrid SPECT/CT imaging
Suh JW, Scheinost D, Dione DP, Dobrucki LW, Sinusas AJ, Papademetris X. A non-rigid registration method for serial lower extremity hybrid SPECT/CT imaging. Medical Image Analysis 2010, 15: 96-111. PMID: 20869902, PMCID: PMC2988883, DOI: 10.1016/j.media.2010.08.002.Peer-Reviewed Original Research
2009
DTI abnormalities in anterior corpus callosum of rats with spike–wave epilepsy
Chahboune H, Mishra AM, DeSalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X, Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H. DTI abnormalities in anterior corpus callosum of rats with spike–wave epilepsy. NeuroImage 2009, 47: 459-466. PMID: 19398019, PMCID: PMC2712639, DOI: 10.1016/j.neuroimage.2009.04.060.Peer-Reviewed Original ResearchConceptsSpike-wave dischargesDiffusion tensor imagingAnterior corpus callosumWAG/RijFractional anisotropyWhite matter pathwaysSeizure activityAbsence epilepsyCorpus callosumDTI abnormalitiesEpileptic WAG/Rij ratsWAG/Rij ratsGenetic Absence Epilepsy RatsCallosal fractional anisotropySomatosensory cortex regionSpike-wave epilepsyBilateral spike-wave dischargesCommon seizure disorderWistar albino Glaxo ratsGlaxo ratsChronic seizuresEpileptic animalsNonepileptic controlsSeizure disorderNeurological difficultiesA Non-rigid Registration Method for Serial microCT Mouse Hindlimb Images
Suh JW, Scheinost D, Dione DP, Dobrucki LW, Sinusas AJ, Papademetris X. A Non-rigid Registration Method for Serial microCT Mouse Hindlimb Images. Lecture Notes In Computer Science 2009, 12: 688-695. PMID: 20426048, PMCID: PMC2856964, DOI: 10.1007/978-3-642-04268-3_85.Peer-Reviewed Original Research