2022
Large-scale differences in functional organization of left- and right-handed individuals using whole-brain, data-driven analysis of connectivity
Tejavibulya L, Peterson H, Greene A, Gao S, Rolison M, Noble S, Scheinost D. Large-scale differences in functional organization of left- and right-handed individuals using whole-brain, data-driven analysis of connectivity. NeuroImage 2022, 252: 119040. PMID: 35272202, PMCID: PMC9013515, DOI: 10.1016/j.neuroimage.2022.119040.Peer-Reviewed Original ResearchConceptsHanded individualsFunctional connectivityLanguage areasWhole-brain functional connectivityRight-handed individualsFunctional organizationWhole-brain levelIndividual differencesHandedness differencesHandedness effectsFunctional connectomeBrain levelsSomatosensory cortexNetworks of interestWhole brainSex differencesBrainConnectomeIndividualsData-driven analysisConnectivityDistinct patternsLateralizationDifferencesSimilar amounts
2016
Language at rest: A longitudinal study of intrinsic functional connectivity in preterm children
Rowlands MA, Scheinost D, Lacadie C, Vohr B, Li F, Schneider KC, Constable R, Ment LR. Language at rest: A longitudinal study of intrinsic functional connectivity in preterm children. NeuroImage Clinical 2016, 11: 149-157. PMID: 26937383, PMCID: PMC4753807, DOI: 10.1016/j.nicl.2016.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsChildFemaleFunctional LateralityHumansIntelligence TestsLanguageLongitudinal StudiesMaleNeural PathwaysRestTemporal LobeConceptsLeft occipito-temporal cortexOccipito-temporal cortexVerbal IQPerformance IQLanguage deficitsSignificant connectivity reductionsPreterm childrenIntrinsic functional connectivityFull IQFunctional connectivity networksFunctional connectivityIQAge 8PT childrenConnectivity reductionLong-range connectionsWorse performanceLinear mixed effects modelsLongitudinal studyConnectivity networksAge 16PT subjectsTS childrenCortical connectivityTerm children
2014
Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born
Kwon SH, Scheinost D, Lacadie C, Sze G, Schneider KC, Dai F, Constable RT, Ment LR. Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born. NeuroImage 2014, 108: 144-150. PMID: 25528658, PMCID: PMC4324328, DOI: 10.1016/j.neuroimage.2014.12.032.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalBrainFemaleFunctional LateralityHumansInfant, Extremely PrematureInfant, NewbornMagnetic Resonance ImagingMaleNerve NetConceptsTerm-equivalent agePreterm neonatesPreterm subjectsCerebral lateralizationTerm control subjectsVery preterm subjectsVery preterm neonatesDegree of prematurityImpact of prematurityInter-hemispheric connectivityEquivalent agePreterm birthPreterm infantsThird trimesterControl subjectsBrain injuryLess lateralizationTerm controlsVoxel-based measureFunctional connectivityCortical organizationBA22Interest analysisWernicke's areaYoung adulthoodAltered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity
Lee HW, Arora J, Papademetris X, Tokoglu F, Negishi M, Scheinost D, Farooque P, Blumenfeld H, Spencer DD, Constable RT. Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity. Neurology 2014, 83: 2269-2277. PMID: 25391304, PMCID: PMC4277677, DOI: 10.1212/wnl.0000000000001068.Peer-Reviewed Original ResearchConceptsSeizure onset zoneIntrinsic connectivity contrastTemporal lobe epilepsyLobe epilepsySurgical outcomesOnset zoneExtratemporal lobe epilepsyIntractable partial epilepsyGood surgical outcomeAltered functional connectivityFunctional connectivity changesResting-state fMRIGlobal network changesEpileptic hemisphereClinical factorsPartial epilepsyEpileptogenic networksEpileptogenic zoneSeizure localizationFocal epilepsyIntracranial EEG recordingsTLE groupIndependent reviewersConnectivity abnormalitiesPatientsCerebral Lateralization is Protective in the Very Prematurely Born
Scheinost D, Lacadie C, Vohr BR, Schneider KC, Papademetris X, Constable RT, Ment LR. Cerebral Lateralization is Protective in the Very Prematurely Born. Cerebral Cortex 2014, 25: 1858-1866. PMID: 24451659, PMCID: PMC4459290, DOI: 10.1093/cercor/bht430.Peer-Reviewed Original ResearchConceptsVery preterm participantsPreterm participantsCerebral lateralizationFunctional connectivityPreterm birth altersSevere brain injuryPreterm brainBrain injuryBirth altersTemporal lobeTerm controlsVoxel-based measureDevelopmental delayRight hemisphere lateralizationTerm participantsLateralizationYoung adulthoodSignificant decreaseCerebral asymmetryFurther studiesHemisphere lateralizationLanguage scoresBrainParticipantsAlterations