2024
The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-up
2022
Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank
Jiang R, Westwater ML, Noble S, Rosenblatt M, Dai W, Qi S, Sui J, Calhoun VD, Scheinost D. Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank. BMC Medicine 2022, 20: 286. PMID: 36076200, PMCID: PMC9461129, DOI: 10.1186/s12916-022-02490-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiological Specimen BanksBrainCross-Sectional StudiesFemaleHand StrengthHumansMaleMental HealthUnited KingdomConceptsGray matter volumeMental healthBrain structuresCognitive declineMatter volumeMental health outcomesHigher life satisfactionBetter mental healthBaseline grip strengthNeural correlatesCognitive functioningCognitive performanceBaseline neuroticismAnxiety symptomsBehavioral outcomesLife satisfactionMediation analysisNeuroimaging datasetsTemporal cortexOlder adultsLinear mixed effects modelsSubcortical regionsFinancial satisfactionLongitudinal dataGrip strengthA functional connectome signature of blood pressure in >30 000 participants from the UK biobank.
Jiang R, Calhoun VD, Noble S, Sui J, Liang Q, Qi S, Scheinost D. A functional connectome signature of blood pressure in >30 000 participants from the UK biobank. Cardiovascular Research 2022, 119: 1427-1440. PMID: 35875865, PMCID: PMC10262183, DOI: 10.1093/cvr/cvac116.Peer-Reviewed Original ResearchMeSH KeywordsBiological Specimen BanksBlood PressureBrainConnectomeHumansMagnetic Resonance ImagingUnited KingdomConceptsBlood pressureBP levelsSystolic/diastolic blood pressurePrevalent modifiable risk factorFunctional connectivityMeaningful blood pressureDiastolic blood pressureElevated blood pressureModifiable risk factorsBody mass indexWhole-brain functional connectivityCentral autonomic networkAnterior cingulate cortexAntihypertensive medicationsMass indexMultiple confoundersPulse pressureRisk factorsCardiovascular diseaseIrreversible structural damageMedicated participantsMedication statusCingulate cortexCognitive declineAlzheimer's disease