2023
Transdiagnostic Connectome-Based Prediction of Craving
Garrison K, Sinha R, Potenza M, Gao S, Liang Q, Lacadie C, Scheinost D. Transdiagnostic Connectome-Based Prediction of Craving. American Journal Of Psychiatry 2023, 180: 445-453. PMID: 36987598, DOI: 10.1176/appi.ajp.21121207.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingImagery conditionFunctional connectomeSelf-reported cravingStudy of motivationDefault mode networkFunctional connectivity dataIndependent samplesKey phenomenological featuresNeural signaturesTransdiagnostic sampleTransdiagnostic perspectiveMode networkMotivated behaviorCentral constructAddictive disordersHuman behaviorConnectivity dataPhenomenological featuresStrongest predictorCravingTaskSubstance use-related disordersConnectomeIndividuals
2017
Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents
Zakiniaeiz Y, Yip SW, Balodis IM, Lacadie CM, Scheinost D, Constable RT, Mayes LC, Sinha R, Potenza MN. Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents. Drug And Alcohol Dependence 2017, 180: 129-136. PMID: 28888152, PMCID: PMC5808433, DOI: 10.1016/j.drugalcdep.2017.07.030.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureNeutral-relaxing conditionsPCE adolescentsParietal connectivityConnectivity analysisSensory areasAdolescent brain functionFunctional magnetic resonance imagingCue interaction effectsIntrinsic connectivity analysesMedial prefrontal areasSeed-based connectivity analysisSubstance Use InitiationAltered functional connectivityAppetitive cuesObesity vulnerabilityPCE statusNeural responsesCorticolimbic connectivityPrefrontal areasFunctional connectivityCraving scoresUtero drug exposureGroup differencesLess connectivity
2016
Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals
Zakiniaeiz Y, Scheinost D, Seo D, Sinha R, Constable RT. Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals. NeuroImage Clinical 2016, 13: 181-187. PMID: 27981033, PMCID: PMC5144743, DOI: 10.1016/j.nicl.2016.10.019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAUD patientsFunctional connectivityCingulate cortexCox proportional hazards regressionChronic relapsing illnessWhole-brain investigationProportional hazards regressionFunctional connectivity differencesAlcohol-dependent patientsVoxel-wise connectivityNeutral cuesAlcohol-dependent individualsHealthy control participantsFunctional magnetic resonanceRelapse measuresHazards regressionSubsequent relapseDependent patientsInpatient treatmentAlcohol relapseFuture relapsePatientsAlcohol dependenceConnectivity differences