2020
Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation
Blaine SK, Wemm S, Fogelman N, Lacadie C, Seo D, Scheinost D, Sinha R. Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation. American Journal Of Psychiatry 2020, 177: 1048-1059. PMID: 32854534, PMCID: PMC7606814, DOI: 10.1176/appi.ajp.2020.19070703.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment initiationAlcohol abstinenceHeavy drinkingFunctional MRIEarly treatment outcomesEarly treatment phaseHealthy control subjectsEarly outpatient treatmentNumber of daysStress imagesDrinking outcomesChronic alcohol abuseHeavy drinking daysSignificant hyperreactivityControl subjectsOutpatient treatmentStriatal dysfunctionEarly treatmentTreatment outcomesBrain stressFunctional pathologyProspective assessmentTreatment phaseAlcohol abuse
2019
Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes
Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang JJ. Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: dgz004. PMID: 31511876, PMCID: PMC6936965, DOI: 10.1210/clinem/dgz004.Peer-Reviewed Original ResearchConceptsState functional connectivityHealthy controlsDefault mode networkType 1 diabetes mellitusFunctional connectivityImpact of T1DMAcademic medical centerAngular gyrus connectivityBlood oxygenation levelState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessDiabetes mellitusHypoglycemic clampHypoglycemia awarenessFunctional outcomeMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHC volunteersType 1
2017
Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder
Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology 2017, 43: 1119-1127. PMID: 28944772, PMCID: PMC5854800, DOI: 10.1038/npp.2017.229.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAnterior cingulate cortexIntrinsic functional connectivityMedial prefrontal cortexFunctional connectivityLarge-scale brain networksDepressive disorderMDD groupAnatomical covarianceBrain networksUnmedicated major depressive disorderWhole-brain intrinsic functional connectivitySystem-level disorderIntrinsic connectivity distributionRegional brain structureMultiple brain networksAltered connectivityCommon findingHealthy comparison participantsDepressive symptomsAltered volumeUnmedicated individualsLocal circuitryCingulate cortexDepressive symptomatology
2016
Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers
Garrison KA, Sinha R, Lacadie CM, Scheinost D, Jastreboff AM, Constable RT, Potenza MN. Functional Connectivity During Exposure to Favorite-Food, Stress, and Neutral-Relaxing Imagery Differs Between Smokers and Nonsmokers. Nicotine & Tobacco Research 2016, 18: 1820-1829. PMID: 26995796, PMCID: PMC4978981, DOI: 10.1093/ntr/ntw088.Peer-Reviewed Original ResearchConceptsFunctional connectivityBrain regionsSupramarginal gyrusFavorite-food cuesSmoking-related alterationsMagnetic resonance imaging studyBrain functional connectivity patternsPrevious functional magnetic resonance imaging (fMRI) studiesTobacco use disorderBrain networksIntrinsic connectivity distributionResonance imaging studyFunctional magnetic resonance imaging studyFunctional connectivity patternsMultiple brain networksSmoking cessationNonsmokersPosterior insulaRolandic operculumSmokersFunctional brain networksImaging studiesGreater connectivityNeural responsesRecent reports
2014
GABA, Resting-State Connectivity and the Developing Brain
Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT, Ment LR. GABA, Resting-State Connectivity and the Developing Brain. Neonatology 2014, 106: 149-155. PMID: 24970028, PMCID: PMC4134402, DOI: 10.1159/000362433.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidTerm-equivalent agePreterm infantsGABA concentrationTerm controlsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansResting-state functional connectivityRegional GABA concentrationTerm control groupResonance imaging scansResting-state connectivityRight frontal lobeConcentration of GABANAA/cholineMagnetic resonance spectroscopyPreclinical dataImaging scansFrontal lobeControl groupInfantsBrainMRI dataAgeCoupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data
Scheinost D, Shen X, Finn E, Sinha R, Constable RT, Papademetris X. Coupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data. PLOS ONE 2014, 9: e93544. PMID: 24676034, PMCID: PMC3968179, DOI: 10.1371/journal.pone.0093544.Peer-Reviewed Original ResearchConceptsHealthy controlsIntrinsic connectivity distributionCocaine-dependent subjectsResting-state scansSeed-based analysisConnectivity analysisSimilar brain regionsBasic neuroscience researchMagnetic resonance imaging dataPsychiatric diseasesVoxel-based resultsConnectivity differencesBrain regionsClinical toolFunctional changesFunctional magnetic resonance imaging (fMRI) dataScansVoxel-based methodConnectivity approachNeuroscience researchConnectivity data
2013
A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes
Mitchell MR, Balodis IM, DeVito EE, Lacadie CM, Yeston J, Scheinost D, Constable RT, Carroll KM, Potenza MN. A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: associations with treatment outcomes. The American Journal Of Drug And Alcohol Abuse 2013, 39: 392-402. PMID: 24200209, PMCID: PMC3827911, DOI: 10.3109/00952990.2013.841711.Peer-Reviewed Original ResearchConceptsTreatment outcomesComparison subjectsCocaine-dependent patientsIntrinsic connectivityCocaine dependenceSubstantia nigraVentral striatumTreatment-seeking cocaine-dependent patientsHealthy comparison subjectsPotential treatment targetGreater intrinsic connectivityRegional brain activationCocaine-dependent groupIntrinsic connectivity analysesNon-addicted individualsBasal gangliaInferior frontal gyrusCocaine-dependent individualsTreatment targetsFMRI Stroop taskSubcortical regionsCocaine abstinenceBrain regionsAnterior insulaFrontal gyrus