2017
Fine Motor Skill Mediates Visual Memory Ability with Microstructural Neuro-correlates in Cerebellar Peduncles in Prematurely Born Adolescents
Thomas AR, Lacadie C, Vohr B, Ment LR, Scheinost D. Fine Motor Skill Mediates Visual Memory Ability with Microstructural Neuro-correlates in Cerebellar Peduncles in Prematurely Born Adolescents. Cerebral Cortex 2017, 27: 322-329. PMID: 28108493, PMCID: PMC5939198, DOI: 10.1093/cercor/bhw415.Peer-Reviewed Original ResearchConceptsGrooved Pegboard TestFine motor skillsVisual-motor integrationRey-Osterrieth Complex Figure TestCerebellar peduncleFractional anisotropyBrain injuryGPT scoresMotor skillsBilateral middle cerebellar pedunclesNeonatal brain injuryDiffusion-weighted magnetic resonance imagingRight superior cerebellar peduncleAge 16 yearsSuperior cerebellar peduncleMiddle cerebellar peduncleBeery Visual Motor IntegrationMagnetic resonance imagingRisk of deficitsWhite matter microstructurePegboard TestPretermResonance imagingComplex Figure TestTerm controls
2016
Prenatal stress alters amygdala functional connectivity in preterm neonates
Scheinost D, Kwon SH, Lacadie C, Sze G, Sinha R, Constable RT, Ment LR. Prenatal stress alters amygdala functional connectivity in preterm neonates. NeuroImage Clinical 2016, 12: 381-388. PMID: 27622134, PMCID: PMC5009231, DOI: 10.1016/j.nicl.2016.08.010.Peer-Reviewed Original ResearchConceptsPrenatal stress exposurePreterm neonatesPreterm birthPrenatal stressStress exposureTerm controlsFunctional connectivityAmygdala connectivityNeuropsychiatric disordersResting-state functional magnetic resonance imagingPrenatal stress altersEarly life stressFunctional magnetic resonance imagingMagnetic resonance imagingPeristriate cortexPrenatal exposureHigh riskMaternal stressIndependent cohortNeonatesLeft amygdalaSubcortical regionsResonance imagingAmygdalaCohort
2014
Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born
Kwon SH, Scheinost D, Lacadie C, Sze G, Schneider KC, Dai F, Constable RT, Ment LR. Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born. NeuroImage 2014, 108: 144-150. PMID: 25528658, PMCID: PMC4324328, DOI: 10.1016/j.neuroimage.2014.12.032.Peer-Reviewed Original ResearchConceptsTerm-equivalent agePreterm neonatesPreterm subjectsCerebral lateralizationTerm control subjectsVery preterm subjectsVery preterm neonatesDegree of prematurityImpact of prematurityInter-hemispheric connectivityEquivalent agePreterm birthPreterm infantsThird trimesterControl subjectsBrain injuryLess lateralizationTerm controlsVoxel-based measureFunctional connectivityCortical organizationBA22Interest analysisWernicke's areaYoung adulthoodGABA, Resting-State Connectivity and the Developing Brain
Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT, Ment LR. GABA, Resting-State Connectivity and the Developing Brain. Neonatology 2014, 106: 149-155. PMID: 24970028, PMCID: PMC4134402, DOI: 10.1159/000362433.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidTerm-equivalent agePreterm infantsGABA concentrationTerm controlsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansResting-state functional connectivityRegional GABA concentrationTerm control groupResonance imaging scansResting-state connectivityRight frontal lobeConcentration of GABANAA/cholineMagnetic resonance spectroscopyPreclinical dataImaging scansFrontal lobeControl groupInfantsBrainMRI dataAgeCerebral Lateralization is Protective in the Very Prematurely Born
Scheinost D, Lacadie C, Vohr BR, Schneider KC, Papademetris X, Constable RT, Ment LR. Cerebral Lateralization is Protective in the Very Prematurely Born. Cerebral Cortex 2014, 25: 1858-1866. PMID: 24451659, PMCID: PMC4459290, DOI: 10.1093/cercor/bht430.Peer-Reviewed Original ResearchConceptsVery preterm participantsPreterm participantsCerebral lateralizationFunctional connectivityPreterm birth altersSevere brain injuryPreterm brainBrain injuryBirth altersTemporal lobeTerm controlsVoxel-based measureDevelopmental delayRight hemisphere lateralizationTerm participantsLateralizationYoung adulthoodSignificant decreaseCerebral asymmetryFurther studiesHemisphere lateralizationLanguage scoresBrainParticipantsAlterations
2012
A left cerebellar pathway mediates language in prematurely-born young adults
Constable RT, Vohr BR, Scheinost D, Benjamin JR, Fulbright RK, Lacadie C, Schneider KC, Katz KH, Zhang H, Papademetris X, Ment LR. A left cerebellar pathway mediates language in prematurely-born young adults. NeuroImage 2012, 64: 371-378. PMID: 22982585, PMCID: PMC3508203, DOI: 10.1016/j.neuroimage.2012.09.008.Peer-Reviewed Original ResearchConceptsPT subjectsTerm controlsInferior frontal gyrusFunctional MRIFunctional connectivityResting-state functional MRIYoung adultsCognitive outcomesSeed-based connectivity analysisAge 20 yearsSeed-based analysisAlternative neural pathwaysControl young adultsPreterm subjectsCerebellar connectivityNeural pathwaysCerebellar pathwaysIndex scoreNineteen ptsGray matterMaternal educationQuadrangular lobuleDevelopmental delayPT brainSignificant positive correlation