2023
Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort
Westwater M, Mallard T, Warrier V, Bethlehem R, Scheinost D, Grillon C, Fletcher P, Seidlitz J, Ernst M. Assessing a multivariate model of brain-mediated genetic influences on disordered eating in the ABCD cohort. Nature Mental Health 2023, 1: 573-585. DOI: 10.1038/s44220-023-00101-4.Peer-Reviewed Original ResearchNeurobiological factorsPsychopathology symptomsFactor scoresCanonical brain networksThree-factor structureStructural equation modelingCritical developmental periodGray matter volumeCortical thicknessGreater genetic riskDisorder symptomatologyABCD studyEarly adolescenceDefault modeBrain networksAnxiety disordersGenetic riskIntervention effortsABCD cohortEquation modelingSubcortical gray matter volumesPsychopathology factorDevelopmental periodFear factorBrain structuresElevated C-reactive protein mediates the liver-brain axis: a preliminary study
Jiang R, Wu J, Rosenblatt M, Dai W, Rodriguez R, Sui J, Qi S, Liang Q, Xu B, Meng Q, Calhoun V, Scheinost D. Elevated C-reactive protein mediates the liver-brain axis: a preliminary study. EBioMedicine 2023, 93: 104679. PMID: 37356206, PMCID: PMC10320521, DOI: 10.1016/j.ebiom.2023.104679.Peer-Reviewed Original ResearchConceptsRegional gray matter volumeGray matter volumeCognitive functioningMost cognitive measuresUnderlying neurobiological factorsEffect sizeLarge effect sizesProspective memoryVisual memoryCognitive measuresExecutive functionTrail MakingCognitive performanceNeurobiological factorsSmall effect sizesProcessing speedVentral striatumParahippocampal gyrusCognitive declineCognitive impairmentMatter volumeMemoryFunctioningCross-sectional associationsLimited researchAssociations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank
Jiang R, Noble S, Sui J, Yoo K, Rosenblatt M, Horien C, Qi S, Liang Q, Sun H, Calhoun V, Scheinost D. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank. The Lancet Digital Health 2023, 5: e350-e359. PMID: 37061351, PMCID: PMC10257912, DOI: 10.1016/s2589-7500(23)00043-2.Peer-Reviewed Original ResearchConceptsPopulation-based studyPhysical frailtyHealth-related outcomesBrain structuresMental healthHealth outcomesHealth measuresTotal white matter hyperintensitiesIndicators of frailtySeverity of frailtyLower gray matter volumePoor physical fitnessWhite matter hyperintensitiesGray matter volumeUK BiobankHealth-related measuresPoor mental healthMental health measuresDirection of associationMatter hyperintensitiesUnhealthy lifestyleEarly-life risksPsychiatric disordersNumerous confoundersPreventative strategies
2022
Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank
Jiang R, Westwater ML, Noble S, Rosenblatt M, Dai W, Qi S, Sui J, Calhoun VD, Scheinost D. Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank. BMC Medicine 2022, 20: 286. PMID: 36076200, PMCID: PMC9461129, DOI: 10.1186/s12916-022-02490-2.Peer-Reviewed Original ResearchConceptsGray matter volumeMental healthBrain structuresCognitive declineMatter volumeMental health outcomesHigher life satisfactionBetter mental healthBaseline grip strengthNeural correlatesCognitive functioningCognitive performanceBaseline neuroticismAnxiety symptomsBehavioral outcomesLife satisfactionMediation analysisNeuroimaging datasetsTemporal cortexOlder adultsLinear mixed effects modelsSubcortical regionsFinancial satisfactionLongitudinal dataGrip strength
2018
Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence
Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence. Chronic Stress 2018, 2: 2470547018786390. PMID: 30035247, PMCID: PMC6054445, DOI: 10.1177/2470547018786390.Peer-Reviewed Original ResearchPosttraumatic stress disorderIntrinsic connectivity distributionMedial prefrontal cortexTensor-based morphometryPTSD groupFunctional connectivityPrefrontal cortexPathophysiology of PTSDGray matter volumeWhole-brain connectivityKey brain regionsMiddle temporal gyrusDorsolateral prefrontal cortexDefault mode networkCentral executive networkFunctional connectivity analysisPFC alterationsCortical alterationsHealthy comparison participantsAltered volumeFunctional alterationsMatter volumeUnmedicated individualsCerebellar involvementBrain regions