2022
A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults
Goldman DA, Sankar A, Rich A, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults. Journal Of Affective Disorders 2022, 319: 15-26. PMID: 36103935, PMCID: PMC9669784, DOI: 10.1016/j.jad.2022.09.016.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsMajor depressive disorderDepressive disorderYoung adultsICD increasesBipolar disorderInterhemispheric functional connectivityFunctional connectivity differencesSeed-based analysisFunctional connectivity patternsSeed-based connectivityFunctional magnetic resonanceFunctional connectivity measuresBasal gangliaFunctional dysconnectivityIllness progressionTreatment strategiesClinical measuresEarly diagnosisHC groupTargeted treatmentConnectivity differencesSuicide thoughtsFunctional connectivityDeleterious treatment
2017
Multi-modal analysis of functional connectivity and cerebral blood flow reveals shared and unique effects of propofol in large-scale brain networks
Qiu M, Scheinost D, Ramani R, Constable RT. Multi-modal analysis of functional connectivity and cerebral blood flow reveals shared and unique effects of propofol in large-scale brain networks. NeuroImage 2017, 148: 130-140. PMID: 28069540, PMCID: PMC5410383, DOI: 10.1016/j.neuroimage.2016.12.080.Peer-Reviewed Original ResearchConceptsCerebral blood flowIntrinsic connectivity distributionLarge-scale brain networksFunctional connectivityReduced consciousnessBlood flowBrain networksSedation conditionsWhole-brain connectivityAltered connectivityMotor networkCBF dataRs-fMRIPharmacological alterationsConnectivity differencesPropofolMultiple large-scale brain networksUnique neural correlatesBlow flowFrontoparietal networkAnesthesiaKey markersDefault modeNeural correlatesSame subjects
2016
Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals
Zakiniaeiz Y, Scheinost D, Seo D, Sinha R, Constable RT. Cingulate cortex functional connectivity predicts future relapse in alcohol dependent individuals. NeuroImage Clinical 2016, 13: 181-187. PMID: 27981033, PMCID: PMC5144743, DOI: 10.1016/j.nicl.2016.10.019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAUD patientsFunctional connectivityCingulate cortexCox proportional hazards regressionChronic relapsing illnessWhole-brain investigationProportional hazards regressionFunctional connectivity differencesAlcohol-dependent patientsVoxel-wise connectivityNeutral cuesAlcohol-dependent individualsHealthy control participantsFunctional magnetic resonanceRelapse measuresHazards regressionSubsequent relapseDependent patientsInpatient treatmentAlcohol relapseFuture relapsePatientsAlcohol dependenceConnectivity differences
2014
Coupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data
Scheinost D, Shen X, Finn E, Sinha R, Constable RT, Papademetris X. Coupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data. PLOS ONE 2014, 9: e93544. PMID: 24676034, PMCID: PMC3968179, DOI: 10.1371/journal.pone.0093544.Peer-Reviewed Original ResearchConceptsHealthy controlsIntrinsic connectivity distributionCocaine-dependent subjectsResting-state scansSeed-based analysisConnectivity analysisSimilar brain regionsBasic neuroscience researchMagnetic resonance imaging dataPsychiatric diseasesVoxel-based resultsConnectivity differencesBrain regionsClinical toolFunctional changesFunctional magnetic resonance imaging (fMRI) dataScansVoxel-based methodConnectivity approachNeuroscience researchConnectivity data
2012
The intrinsic connectivity distribution: A novel contrast measure reflecting voxel level functional connectivity
Scheinost D, Benjamin J, Lacadie CM, Vohr B, Schneider KC, Ment LR, Papademetris X, Constable RT. The intrinsic connectivity distribution: A novel contrast measure reflecting voxel level functional connectivity. NeuroImage 2012, 62: 1510-1519. PMID: 22659477, PMCID: PMC3538880, DOI: 10.1016/j.neuroimage.2012.05.073.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity distributionTerm control subjectsFunctional connectivity differencesControl subjectsVoxel-level functional connectivityConnectivity differencesResting-state fMRIDisease groupTemporal-parietal areasPsychiatric disordersRs-fMRINeurological disordersClinical toolFunctional connectivityYoung adultsFMRI measuresRelevant differencesDisordersSubjectsLanguage processing areasSurvey studyTissue connectivityPretermDifferences