2023
Everglades virus: an underrecognized disease-causing subtype of Venezuelan equine encephalitis virus endemic to Florida, USA
Burkett-Cadena N, Fish D, Weaver S, Vittor A. Everglades virus: an underrecognized disease-causing subtype of Venezuelan equine encephalitis virus endemic to Florida, USA. Journal Of Medical Entomology 2023, 60: 1149-1164. PMID: 37862065, PMCID: PMC10645373, DOI: 10.1093/jme/tjad070.Peer-Reviewed Original ResearchConceptsEverglades virusEncephalitis virusCases of meningitisCotton rat Sigmodon hispidusHigh natural infection rateEpidemic strainsNatural infection rateInfection rateWidespread transmissionAbundance of AedesNatural infectionSubtype IISubtypesFrequent feedingFrequency of contactCertain mosquitoesVector competenceVirusHuman diseasesRodentsVertebrate hosts
2017
Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections
Rynkiewicz EC, Brown J, Tufts DM, Huang CI, Kampen H, Bent SJ, Fish D, Diuk-Wasser MA. Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections. Parasites & Vectors 2017, 10: 64. PMID: 28166814, PMCID: PMC5292797, DOI: 10.1186/s13071-016-1964-9.Peer-Reviewed Original ResearchConceptsAsymmetric competitive interactionsPatterns of coexistenceBiotic contextCommon disease vectorPathogen communitiesVector-borne pathogensBorrelia burgdorferiLong-term persistencePathogen speciesAsymmetric competitionPathogen dynamicsInfection phenotypesSimilar fitnessTransmission phenotypeDisease vectorsTemperate regionsCompetitive interactionsTransmission advantagePathogen strainsPathogen persistenceBlack-legged tickCompetitive strainsPeromyscus leucopusWhite-footed miceHost
2014
Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States
Dunn JM, Krause PJ, Davis S, Vannier EG, Fitzpatrick MC, Rollend L, Belperron AA, States SL, Stacey A, Bockenstedt LK, Fish D, Diuk-Wasser MA. Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States. PLOS ONE 2014, 9: e115494. PMID: 25545393, PMCID: PMC4278703, DOI: 10.1371/journal.pone.0115494.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBabesia microtiBabesiosisBorrelia burgdorferiCoinfectionIxodesNew EnglandPeromyscusConceptsB. microtiB. burgdorferiBabesia microtiLyme diseaseRespective causative agentsSpread of babesiosisI. scapularis larvaeInfected micePrimary reservoir hostHigh prevalenceLeucopus miceMiceHuman babesiosisBorrelia burgdorferiLaboratory dataLarval burdenCausative agentMicrotiBurgdorferiCoinfectionReservoir hostsDiseaseR0 modelBasic reproduction numberEnzootic cycle
2012
Identification of Borrelia burgdorferi ospC Genotypes in Host Tissue and Feeding Ticks by Terminal Restriction Fragment Length Polymorphisms
Tsao K, Bent S, Fish D. Identification of Borrelia burgdorferi ospC Genotypes in Host Tissue and Feeding Ticks by Terminal Restriction Fragment Length Polymorphisms. Applied And Environmental Microbiology 2012, 79: 958-964. PMID: 23183976, PMCID: PMC3568573, DOI: 10.1128/aem.03106-12.Peer-Reviewed Original ResearchPredicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease
Tsao K, Fish D, Galvani AP. Predicted Outcomes of Vaccinating Wildlife to Reduce Human Risk of Lyme Disease. Vector-Borne And Zoonotic Diseases 2012, 12: 544-551. PMID: 22251312, DOI: 10.1089/vbz.2011.0731.Peer-Reviewed Original ResearchConceptsMice vaccinationTick biteB. burgdorferi transmissionLyme disease preventionTick blood mealVaccination outcomesHuman riskVaccination effortsDisease preventionLyme diseaseVaccinationInfection prevalenceBorrelia burgdorferiMiceWildlife vaccinationB. burgdorferiCausative agentPredicted outcomeBlood mealVector ticksBiteOutcomesBurgdorferiRiskWildlife reservoirs
2009
Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir Species
Barbour A, Bunikis J, Travinsky B, Hoen A, Diuk-Wasser M, Fish D, Tsao J. Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir Species. American Journal Of Tropical Medicine And Hygiene 2009, 81: 1120-1131. PMID: 19996447, PMCID: PMC2841027, DOI: 10.4269/ajtmh.2009.09-0208.Peer-Reviewed Original Research
2007
Fitness Variation of Borrelia burgdorferi Sensu Stricto Strains in Mice
Hanincová K, Ogden NH, Diuk-Wasser M, Pappas CJ, Iyer R, Fish D, Schwartz I, Kurtenbach K. Fitness Variation of Borrelia burgdorferi Sensu Stricto Strains in Mice. Applied And Environmental Microbiology 2007, 74: 153-157. PMID: 17981941, PMCID: PMC2223198, DOI: 10.1128/aem.01567-07.Peer-Reviewed Original Research
2004
An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle
Tsao J, Wootton J, Bunikis J, Luna M, Fish D, Barbour A. An ecological approach to preventing human infection: Vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 18159-18164. PMID: 15608069, PMCID: PMC536054, DOI: 10.1073/pnas.0405763102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiCommunicable DiseasesDisease ReservoirsEcologyGenotypeGlutathione TransferaseHumansImmunoenzyme TechniquesIxodesLipoproteinsLyme DiseaseMicePeromyscusPolymerase Chain ReactionRecombinant Fusion ProteinsTicksVaccinesConceptsWild white-footed miceTick infection prevalenceNegative control antigenReservoir host speciesVector-borne diseasesSympatric ticksField experimentDisease cycleB. burgdorferiDisease incidenceDisease agentsArthropod vectorsEcological approachAnimal reservoirsImmunization of humansMouse densityTicksHost speciesLyme disease agentInfection dynamicsHuman vaccinesPopulation structureWhite-footed miceOuter surface protein AHuman infectionsInteraction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System
Derdáková M, Dudiòák V, Brei B, Brownstein J, Schwartz I, Fish D. Interaction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System. Applied And Environmental Microbiology 2004, 70: 6783-6788. PMID: 15528545, PMCID: PMC525125, DOI: 10.1128/aem.70.11.6783-6788.2004.Peer-Reviewed Original ResearchConceptsB. burgdorferi sensu strictoBurgdorferi sensu strictoXenodiagnostic ticksBorrelia burgdorferi sensu strictoUninfected larval ticksGroups of miceWhite-footed miceTransmission cycleControl miceInfected micePrimary infectionExperimental miceI. scapularis ticksLeucopus miceDouble infectionMiceLyme disease agentInfectionScapularis ticksMajor genotypesWeekly intervalsTransmission dynamicsExperimental groupSame strainLarval ticksBorrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic
Bunikis J, Tsao J, Luke C, Luna M, Fish D, Barbour A. Borrelia burgdorferi Infection in a Natural Population of Peromyscus Leucopus Mice: A Longitudinal Study in an Area Where Lyme Borreliosis Is Highly Endemic. The Journal Of Infectious Diseases 2004, 189: 1515-1523. PMID: 15073690, DOI: 10.1086/382594.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialBacterial Outer Membrane ProteinsBlotting, WesternBorrelia burgdorferiConnecticutDisease ReservoirsDNA, BacterialEndemic DiseasesFemaleImmunoenzyme TechniquesIncidenceIxodesLongitudinal StudiesLyme DiseasePeromyscusPolymerase Chain ReactionRodent DiseasesSeasonsSeroepidemiologic StudiesConceptsPeromyscus leucopus miceLeucopus miceTransmission seasonBorrelia burgdorferi infectionPolymerase chain reactionSurface protein CBurgdorferi infectionBlood samplesMice ageEnzyme immunoassayLyme borreliosisMiceSerum samplesProtein CDynamics of infectionBorrelia burgdorferiB. burgdorferiChain reactionLongitudinal studyEnzootic siteInfectionAntibodiesEntire populationBurgdorferiIxodes scapularis
2002
Comparison of the Reservoir Competence of Medium-Sized Mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut
Levin M, Nicholson W, Massung R, Sumner J, Fish D. Comparison of the Reservoir Competence of Medium-Sized Mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut. Vector-Borne And Zoonotic Diseases 2002, 2: 125-136. PMID: 12737542, DOI: 10.1089/15303660260613693.Peer-Reviewed Original Research
2001
Interference Between the Agents of Lyme Disease and Human Granulocytic Ehrlichiosis in a Natural Reservoir Host
Levin M, Fish D. Interference Between the Agents of Lyme Disease and Human Granulocytic Ehrlichiosis in a Natural Reservoir Host. Vector-Borne And Zoonotic Diseases 2001, 1: 139-148. PMID: 12653144, DOI: 10.1089/153036601316977741.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisE. phagocytophilaB. burgdorferiGranulocytic ehrlichiosisLyme diseaseB. burgdorferi challengeGroups of miceB. burgdorferi-infected miceBurgdorferi-infected miceXenodiagnostic larvaeI. scapularis larvaeUninfected miceNatural reservoir hostsControl miceInfectious challengePrimary infectionXenodiagnostic ticksControl groupMiceInfectionMixed infectionsI. scapularis nymphsBurgdorferiWeekly intervalsSecond agentOspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks
Tsao J, Barbour A, Luke C, Fikrig E, Fish D. OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks. Vector-Borne And Zoonotic Diseases 2001, 1: 65-74. PMID: 12653137, DOI: 10.1089/153036601750137705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, WildAntibodies, BacterialAntigens, SurfaceArachnid VectorsBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiDisease ReservoirsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFluorescent Antibody Technique, DirectHost-Parasite InteractionsIxodesLarvaLipoproteinsLyme DiseasePeromyscusConceptsControl miceUninfected larval ticksInfection prevalenceLarval Ixodes scapularis ticksB. burgdorferiNumber of spirochetesEnzyme-linked immunosorbentBorrelia burgdorferi spirochetesLevel of immunizationReservoir hostsConcentration of antibodyBorrelia burgdorferi transmissionIxodes scapularis ticksSecond vaccinationImmunized miceInfected miceLarval ticksPrior infectionVaccination programSubsequent riskDecrease transmissionOspA vaccinationDirect immunofluorescenceImmune responseXenodiagnostic ticksA Relapsing Fever Group Spirochete Transmitted by Ixodes scapularis Ticks
Scoles G, Papero M, Beati L, Fish D. A Relapsing Fever Group Spirochete Transmitted by Ixodes scapularis Ticks. Vector-Borne And Zoonotic Diseases 2001, 1: 21-34. PMID: 12653133, DOI: 10.1089/153036601750137624.Peer-Reviewed Original ResearchAnimalsAntigens, BacterialAntigens, SurfaceArachnid VectorsBacterial Outer Membrane ProteinsBacterial VaccinesBorreliaDNA, BacterialDNA, RibosomalFemaleFlagellinInfectious Disease Transmission, VerticalIxodesLipoproteinsPeromyscusPhylogenyPolymerase Chain ReactionRabbitsRelapsing FeverSequence Homology, Nucleic AcidSheep
2000
Immunity Reduces Reservoir Host Competence of Peromyscus leucopus forEhrlichia phagocytophila
Levin M, Fish D. Immunity Reduces Reservoir Host Competence of Peromyscus leucopus forEhrlichia phagocytophila. Infection And Immunity 2000, 68: 1514-1518. PMID: 10678968, PMCID: PMC97309, DOI: 10.1128/iai.68.3.1514-1518.2000.Peer-Reviewed Original ResearchConceptsE. phagocytophilaControl miceImmune responseNonimmune control miceWhite-footed miceSame agentsMajority of miceStrong immune responsePrevalence of infectionXenodiagnostic larvaeImmunized miceTick biteXenodiagnostic ticksIxodes scapularis nymphsControl groupSingle infectionEhrlichia phagocytophilaMiceUninfected ticksInfectionPartial protectionWeeksImmunityScapularis nymphsReservoir host competence
1999
Disparity in the Natural Cycles of Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis - Volume 5, Number 2—April 1999 - Emerging Infectious Diseases journal - CDC
Levin M, Vignes F, Fish D. Disparity in the Natural Cycles of Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis - Volume 5, Number 2—April 1999 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 1999, 5: 204-208. PMID: 10221871, PMCID: PMC2640706, DOI: 10.3201/eid0502.990203.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisAgent of HGEB. burgdorferi infectionBurgdorferi infectionInfectious Diseases journal - CDCBorrelia burgdorferiWhite-footed miceIxodes scapularis ticksWild white-footed miceDifferent prevalenceGranulocytic ehrlichiosisPrevalenceMiceScapularis ticksInfectionHost-seeking ticksNatural cycleBurgdorferiTicksAgentsEhrlichiosisComparative Vector Competence of Dermacentor variabilis and Ixodes scapularis (Acari: Ixodidae) for the Agent of Human Granulocytic Ehrlichiosis
Vignes F, Levin M, Fish D. Comparative Vector Competence of Dermacentor variabilis and Ixodes scapularis (Acari: Ixodidae) for the Agent of Human Granulocytic Ehrlichiosis. Journal Of Medical Entomology 1999, 36: 182-185. PMID: 10083755, DOI: 10.1093/jmedent/36.2.182.Peer-Reviewed Original ResearchConceptsAgent of HGEHuman granulocytic ehrlichiosisPolymerase chain reactionD. variabilis nymphsGranulocytic ehrlichiosisI. scapularis nymphsEvidence of transmissionVector competenceScapularis nymphsI. scapularisLeucopus miceD. variabilis larvaeMiceDermacentor variabilisComparative vector competenceRepletionChain reactionCompetent vectorsD. variabilisWhite-footed miceTrialsEhrlichiosisAgentsIxodes scapularisIxodes scapularis Say
1998
Density-dependent factors regulating feeding success of Ixodes scapularis larvae (Acari: Ixodidae).
Levin M, Fish D. Density-dependent factors regulating feeding success of Ixodes scapularis larvae (Acari: Ixodidae). Journal Of Parasitology 1998, 84: 36-43. PMID: 9488335, DOI: 10.2307/3284526.Peer-Reviewed Original ResearchConceptsMice fed 2Larval Ixodes scapularis ticksIxodes scapularis ticksReplete larvaeIxodes scapularis larvaeUnattached ticksFed 2MiceScapularis ticksLarval I. scapularisEngorgement weightSolitary miceDifferent parasitesUnfed ticksTicksContinuous infestationI. scapularisGroupFeeding successTick density
1997
Detection of Borrelia burgdorferi OspA in Ixodes scapularis larvae by an antigen-capture enzyme-linked immunosorbent assay.
Mannelli A, Fish D, Daniels T, Kharitonenkov I, Tun H, Cozzolino A, Bucher D. Detection of Borrelia burgdorferi OspA in Ixodes scapularis larvae by an antigen-capture enzyme-linked immunosorbent assay. Microbiologica 1997, 20: 355-9. PMID: 9385607.Peer-Reviewed Original Research
1995
Evidence of hantavirus infection in rodents and human beings from Connecticut and New York, USA
Wilson M, Tesh R, Fish D, Gerber M, Magnarelli L, Feder H, Shapiro E. Evidence of hantavirus infection in rodents and human beings from Connecticut and New York, USA. The Lancet 1995, 345: 738. PMID: 7885165, DOI: 10.1016/s0140-6736(95)90915-x.Peer-Reviewed Original Research