2000
Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis
Pan J, Rothman D, Behar K, Stein D, Hetherington H. Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 1502-1507. PMID: 11043913, DOI: 10.1097/00004647-200010000-00012.Peer-Reviewed Original ResearchConceptsBHB levelsPlasma BHB levelsField magnetic resonance spectroscopyHigh-field magnetic resonance spectroscopyBrain lactateKetogenic dietCalcarine fissureNonfasted stateOccipital lobeHealthy adultsLactate increaseThird dayΒ-hydroxybutyrateKetosisBHB concentrationsBrainBHBGlucose phosphorylationLactate oxidationMagnetic resonance spectroscopy
1992
Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance Spectroscopy
Petroff O, Novotny E, Avison M, Rothman D, Alger J, Ogino T, Shulman G, Prichard J. Cerebral Lactate Turnover after Electroshock: In vivo Measurements by 1H/13C Magnetic Resonance Spectroscopy. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 1022-1029. PMID: 1400641, DOI: 10.1038/jcbfm.1992.139.Peer-Reviewed Original ResearchConceptsBlood lactateLactate poolNuclear magnetic resonance spectroscopyMetabolic stateBrain lactateBlood gasesBlood glucoseElevated lactateMagnetic resonance spectroscopyProlonged elevationRabbit brainPerchloric acid extractsPathological conditionsBrain activationBrainResonance spectroscopyLactate turnoverHigh resolution 1H NMRIntracellular pHElectroshockLactateHuman brainVivo 1HSignificant changesAcid extractsProton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients.
Graham G, Blamire A, Howseman A, Rothman D, Fayad P, Brass L, Petroff O, Shulman R, Prichard J. Proton magnetic resonance spectroscopy of cerebral lactate and other metabolites in stroke patients. Stroke 1992, 23: 333-340. PMID: 1542892, DOI: 10.1161/01.str.23.3.333.Peer-Reviewed Original ResearchConceptsProton magnetic resonance spectroscopyStroke patientsCerebral lactateDeep cerebral infarctsElevated cerebral lactateSmall subcortical infarctsCortical stroke patientsN-acetylaspartate levelsLong-term elevationCerebral infarctsCortical strokeOngoing ischemiaSymptom onsetBrain lactateElevated lactateInitial insultSubcortical infarctsN-acetylaspartateInfarct regionLesion onsetMagnetic resonance spectroscopyInfarctsPatientsFirst weekStroke