2022
Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy
Stuart JJ, Tanz LJ, Rimm EB, Spiegelman D, Missmer SA, Mukamal KJ, Rexrode KM, Rich-Edwards JW. Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy. Journal Of The American College Of Cardiology 2022, 79: 1901-1913. PMID: 35550687, PMCID: PMC9176211, DOI: 10.1016/j.jacc.2022.03.335.Peer-Reviewed Original ResearchConceptsCVD risk factorsRates of CVDHealth Study IIRisk of CVDBody mass indexGestational hypertensionType 2 diabetesRisk factorsChronic hypertensionHypertensive disordersMass indexNurses' Health Study IIPrepregnancy body mass indexHistory of HDPCardiovascular risk factorsOverweight/obesityProportional hazards modelIncident CVDCVD preventionNormotensive pregnanciesFirst pregnancyPotential confoundersParental historyHypertensionHazards modelLong-Term Survival and Causes of Death After Diagnoses of Common Cancers in 3 Cohorts of U.S. Health Professionals
Cheng E, Lee DH, Tamimi RM, Hankinson SE, Willett WC, Giovannucci EL, Eliassen AH, Stampfer MJ, Mucci LA, Fuchs CS, Spiegelman D. Long-Term Survival and Causes of Death After Diagnoses of Common Cancers in 3 Cohorts of U.S. Health Professionals. JNCI Cancer Spectrum 2022, 6: pkac021-. PMID: 35603853, PMCID: PMC8973409, DOI: 10.1093/jncics/pkac021.Peer-Reviewed Original ResearchConceptsCancer-specific mortalityHealth Study IIUterine corpusCause of deathCommon cancerThyroid cancerPrimary cancerCancer survivorsLung cancerCumulative mortalityHealth StudyColorectal cancer-specific mortalityLong-term overall survivalNurses' Health Study IICancer-specific mortality ratesU.S. health professionalsHealth Professionals FollowNurses' Health StudyMale cancer survivorsFemale cancer survivorsProfessionals FollowMost patientsOverall survivalExcess riskUrinary bladder
2020
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study
McGee EE, Kim CH, Wang M, Spiegelman D, Stover DG, Heng YJ, Collins LC, Baker GM, Farvid MS, Schedin P, Jindal S, Tamimi RM, Eliassen AH. Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. Breast Cancer Research 2020, 22: 78. PMID: 32698885, PMCID: PMC7374956, DOI: 10.1186/s13058-020-01316-4.Peer-Reviewed Original ResearchConceptsBreast cancer riskImmuno-inflammatory markersErythrocyte membrane fatty acidsCase-control studyTumor tissue expressionFatty acid synthaseCancer riskTrans fatty acidsExpression subtypesOdds ratioSpecific fatty acidsLogistic regressionHealth Study IITumor tissue blocksMembrane fatty acidsFatty acidsUnconditional logistic regressionConfidence intervalsTissue expressionT cell functionPolytomous logistic regressionAcid synthaseTumor CD4Potential confoundersTumor expression
2010
Erratum to: Maternal Early Life Factors Associated with Hormone Levels and the Risk of Having a Child with an Autism Spectrum Disorder in the Nurses Health Study II
Lyall K, Pauls D, Santangelo S, Spiegelman D, Ascherio A. Erratum to: Maternal Early Life Factors Associated with Hormone Levels and the Risk of Having a Child with an Autism Spectrum Disorder in the Nurses Health Study II. Journal Of Autism And Developmental Disorders 2010, 41: 628-628. DOI: 10.1007/s10803-010-1097-5.Peer-Reviewed Original Research
2005
Dietary Patterns and the Risk of Breast Cancer
Adebamowo CA, Hu FB, Cho E, Spiegelman D, Holmes MD, Willett WC. Dietary Patterns and the Risk of Breast Cancer. Annals Of Epidemiology 2005, 15: 789-795. PMID: 16257363, DOI: 10.1016/j.annepidem.2005.01.008.Peer-Reviewed Original ResearchConceptsPrudent dietary patternDietary patternsBreast cancerNurses' Health Study IIMajor dietary patternsHealth Study IIWestern dietary patternFood frequency questionnaireInvasive breast cancerPre-menopausal womenBreast cancer riskSecular trend studiesCumulative average scoreMultivariate RRsPremenopausal womenFrequency questionnaireLowest quintileInverse associationWestern dietCancer riskOverall associationCancerFurther evaluationStudy IIRiskDietary flavonols and flavonol‐rich foods intake and the risk of breast cancer
Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD. Dietary flavonols and flavonol‐rich foods intake and the risk of breast cancer. International Journal Of Cancer 2005, 114: 628-633. PMID: 15609322, DOI: 10.1002/ijc.20741.Peer-Reviewed Original ResearchConceptsMultivariate relative riskBreast cancer riskCumulative average intakeFlavonol-rich foodsIntake of beansRelative riskBreast cancerCancer riskFlavonol intakeLowest quintileInverse associationDietary flavonolsAverage intakeNurses' Health Study IIIntake of flavonolsHealth Study IIFood frequency questionnaireInvasive breast cancerSignificant inverse associationFrequency questionnaireEpidemiological studiesAnimal studiesDietary dataOverall associationFurther evaluationHigh school dietary dairy intake and teenage acne
Adebamowo CA, Spiegelman D, Danby FW, Frazier AL, Willett WC, Holmes MD. High school dietary dairy intake and teenage acne. Journal Of The American Academy Of Dermatology 2005, 52: 207-214. PMID: 15692464, DOI: 10.1016/j.jaad.2004.08.007.Peer-Reviewed Original ResearchConceptsTeenage acnePrevalence ratiosNurses' Health Study IIDietary dairy intakeHigh school dietMultivariate prevalence ratiosHealth Study IIBody mass indexCategories of intakeLow-fat milkMass indexSchool dietDairy intakeWestern dietPresence of hormoneAcne historyPossible associationAcneEnergy intakeStudy IIIntakeBreakfast drinksConfidence intervalsTotal milkDairy foods
2004
In utero exposures and the incidence of endometriosis
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Michels KB, Hunter DJ. In utero exposures and the incidence of endometriosis. Fertility And Sterility 2004, 82: 1501-1508. PMID: 15589850, DOI: 10.1016/j.fertnstert.2004.04.065.Peer-Reviewed Original ResearchConceptsHealth Study IIIncidence of endometriosisMultiple gestationsFetal environmentNurses' Health Study IIRate of endometriosisProspective cohort studyBody mass indexDiethylstilbestrol exposurePast infertilityPremature deliveryCohort studyMass indexUtero exposureInfertility statusIncidence rateEndometriosis diagnosisMAIN OUTCOMEUS womenEndometriosisAge 18BirthweightStudy IIEffect estimatesWomenSexual Orientation, Health Risk Factors, and Physical Functioning in the Nurses' Health Study II
Case P, Austin SB, Hunter DJ, Manson JE, Malspeis S, Willett WC, Spiegelman D. Sexual Orientation, Health Risk Factors, and Physical Functioning in the Nurses' Health Study II. Journal Of Women's Health 2004, 13: 1033-1047. PMID: 15665660, DOI: 10.1089/jwh.2004.13.1033.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingBisexualityBody Mass IndexBreast NeoplasmsCardiovascular DiseasesCross-Sectional StudiesDepressionFemaleHealth BehaviorHealth StatusHomosexuality, FemaleHumansLinear ModelsMental HealthMiddle AgedMultivariate AnalysisNurse CliniciansPrevalenceProspective StudiesRisk FactorsSmokingTime FactorsUnited StatesConceptsNurses' Health Study IIHealth Study IIBody mass indexRisk factorsHealth risk factorsHigh prevalenceRegion of residenceOverall cohortBreast cancerHealth statusHigher daily alcohol intakeCardiovascular disease risk factorsBreast cancer risk factorsHigher body mass indexStudy IIMultivariate prevalence ratiosDaily alcohol intakeDisease risk factorsUse of antidepressantsCancer risk factorsHealth-related functioningImportant risk factorMental health statusPoor mental healthBisexual women
2003
Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Colditz GA, Willett WC. Premenopausal dietary carbohydrate, glycemic index, glycemic load, and fiber in relation to risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 1153-8. PMID: 14652274.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer riskHealth Study IIGlycemic loadCarbohydrate intakeCancer riskBreast cancerGlycemic indexDietary carbohydrateRelative riskFiber intakeNurses' Health Study IIMultivariate relative riskCorresponding relative risksFood frequency questionnaireInvasive breast cancerDietary carbohydrate intakeEarly adult lifeYoung adult womenPremenopausal womenFrequency questionnaireLean womenOverall cohortOverweight womenMass indexPremenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Zhang SM, Colditz GA, Willett WC. Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 713-20. PMID: 12917201.Peer-Reviewed Original ResearchConceptsHealth Study IIBreast cancer riskBreast cancerVitamin ACancer riskNurses' Health Study IIMultivariate relative riskFood frequency questionnaireInvasive breast cancerPrevious epidemiological studiesEarly adult lifePostmenopausal womenPremenopausal womenIncident casesHighest quintileLowest quintileRelative riskHigh intakeEpidemiological studiesNutrient intakeTotal vitaminCancerStudy IIIntakeVitamin CPremenopausal Fat Intake and Risk of Breast Cancer
Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC. Premenopausal Fat Intake and Risk of Breast Cancer. Journal Of The National Cancer Institute 2003, 95: 1079-1085. PMID: 12865454, DOI: 10.1093/jnci/95.14.1079.Peer-Reviewed Original ResearchConceptsBreast cancer riskDietary fat intakeHigh-fat dairy foodsHealth Study IIFat intakeBreast cancerCancer riskRelative riskPremenopausal womenIncident invasive breast cancerNurses' Health Study IIElevated breast cancer riskRed meatMultivariable relative risksAnimal fat intakeFood frequency questionnaireInvasive breast cancerConfidence intervalsCase-control studyDairy foodsPremenopausal yearsPostmenopausal womenProspective studyHighest quintileLowest quintileA Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women
Kroenke CH, Chu NF, Rifai N, Spiegelman D, Hankinson SE, Manson JE, Rimm EB. A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women. Diabetes Care 2003, 26: 1971-1978. PMID: 12832298, DOI: 10.2337/diacare.26.7.1971.Peer-Reviewed Original ResearchConceptsHealth Study IIGlycemic controlAlcohol intakeBiologic markersNurses' Health Study IIBeneficial glycemic effectsAverage alcohol intakeModerate alcohol consumptionMain outcome measuresCross-sectional studyYears of ageAlcohol consumption patternsOverweight womenGlycemic effectsInsulin levelsLifestyle factorsInsulin resistanceDietary factorsInverse associationC-peptideAverage daily consumptionOutcome measuresPhysical activityBlood samplesAlcohol consumption
2002
Physical Activity, Body Mass Index, and Ovulatory Disorder Infertility
Rich-Edwards JW, Spiegelman D, Garland M, Hertzmark E, Hunter DJ, Colditz GA, Willett WC, Wand H, Manson JE. Physical Activity, Body Mass Index, and Ovulatory Disorder Infertility. Epidemiology 2002, 13: 184-190. PMID: 11880759, DOI: 10.1097/00001648-200203000-00013.Peer-Reviewed Original ResearchConceptsBody mass indexOvulatory disorder infertilityHealth Study IIOvulatory infertilityRelative riskMass indexVigorous activityNurses' Health Study IIVigorous-intensity exerciseLower relative riskAmerican womenAdiposity levelsIntensity exercisePhysical activitySedentary lifestyleBMI distributionInfertilityU.S. womenStudy IIWomenUnderweightRiskWeekly activitiesAssociationHours
2001
Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study
Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernán MA, Olek MJ, Hankinson SE, Hunter DJ. Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study. JAMA 2001, 286: 3083-3088. PMID: 11754673, DOI: 10.1001/jama.286.24.3083.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusViral capsid antigenCases of MSGeometric mean titersHealth Study IIMultiple sclerosisSerum antibody titersRelative riskAntibody titersDisease onsetEBNA-2Health StudyRole of EBVNurses' Health Study IIEBV viral capsid antigenEpstein-Barr virus antibodiesEtiology of MSOccurrence of MSHealthy age-matched controlsNurses' Health StudyCorresponding relative risksCase-control studyAge-matched controlsCMV antigensEBV antibodiesRelationship of a large weight loss to long-term weight change among young and middle-aged US women
Field A, Wing R, Manson J, Spiegelman D, Willett W. Relationship of a large weight loss to long-term weight change among young and middle-aged US women. International Journal Of Obesity 2001, 25: 1113-1121. PMID: 11477495, DOI: 10.1038/sj.ijo.0801643.Peer-Reviewed Original ResearchConceptsHealth Study IIWeight lossPhysical activityNurses' Health Study IILong-term weight changeLong-term weight gainCategories of BMIBody mass indexLarge weight lossVigorous physical activityMiddle-aged womenSignificant weight lossSelf-reported weightDiagnosis of cancerMass indexWeight cyclingDietary intakeCardiovascular diseaseLess weightUS womenMost womenInactive peersBMIWeight gainStudy II
2000
Oral contraceptives and the incidence of multiple sclerosis
Hernán M, Hohol MJ, Olek MJ, Spiegelman D, Ascherio A. Oral contraceptives and the incidence of multiple sclerosis. Neurology 2000, 55: 848-853. PMID: 10994007, DOI: 10.1212/wnl.55.6.848.Peer-Reviewed Original ResearchConceptsRisk of MSHealth Study IIOral contraceptive useOral contraceptivesContraceptive useProtective effectHealth StudyNurses' Health Study IIAge-adjusted relative riskOral contraceptive historiesNurses' Health StudyProgression of MSDiagnosis of MSDuration of useCohort studyMS incidenceMS riskHormonal contraceptionMultiple sclerosisContraceptive historyRelative riskClinical dataProbable casesU.S. womenPast users
1998
Physical Activity and Breast Cancer Risk in a Cohort of Young Women
Rockhill B, Willett W, Hunter D, Manson J, Hankinson S, Spiegelman D, Colditz G. Physical Activity and Breast Cancer Risk in a Cohort of Young Women. Journal Of The National Cancer Institute 1998, 90: 1555-1160. PMID: 9701365, DOI: 10.1093/jnci/90.15.1155.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study IIPhysical activityRelative riskBreast cancerCancer riskNurses' Health Study IIRR of cancerBreast cancer preventionInvasive breast cancerStrenuous physical activityConfidence intervalsLate adolescenceNonoccupational physical activityYoung adult womenProspective studyNonoccupational activitiesActive womenCancer preventionReduced riskStrenuous activityAdult womenAge 18Logistic regressionYoung womenMenstrual Cycle Characteristics and History of Ovulatory Infertility in Relation to Breast Cancer Risk in a Large Cohort of US Women
Garland M, Hunter D, Colditz G, Manson J, Stampfer M, Spiegelman D, Speizer F, Willett W. Menstrual Cycle Characteristics and History of Ovulatory Infertility in Relation to Breast Cancer Risk in a Large Cohort of US Women. American Journal Of Epidemiology 1998, 147: 636-643. PMID: 9554602, DOI: 10.1093/oxfordjournals.aje.a009504.Peer-Reviewed Original ResearchConceptsMultivariate relative riskHealth Study IIMenstrual cycle characteristicsBreast cancer riskRelative riskOvulatory infertilityBreast cancerCancer riskLonger menstrual cycle lengthNurses' Health Study IICycle lengthUsual cycle lengthProspective cohort studyMenstrual cycle lengthOvulatory menstrual cyclesCohort studyBaseline questionnaireMenstrual cycleLarge cohortProtective effectUS womenAge 18Study IIInfertilityCycle characteristics
1997
A Prospective Study of Pregravid Determinants of Gestational Diabetes Mellitus
Solomon CG, Willett WC, Carey VJ, Rich-Edwards J, Hunter DJ, Colditz GA, Stampfer MJ, Speizer FE, Spiegelman D, Manson JE. A Prospective Study of Pregravid Determinants of Gestational Diabetes Mellitus. JAMA 1997, 278: 1078-1083. PMID: 9315766, DOI: 10.1001/jama.1997.03550130052036.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusBody mass indexPregravid body mass indexHealth Study IIDiabetes mellitusGDM riskWeight gainMaternal ageRisk factorsRelative riskFamily historyRisk of GDMNurses' Health Study IIPrevious gestational diabetes mellitusHigher body mass indexNoninsulin-dependent diabetes mellitusGDM risk factorsProspective cohort studyMedical record reviewEarly adulthoodPossible preventive strategiesIdentification of womenSubstantial weight gainAdvanced maternal ageGreater weight gain