Featured Publications
Emerging roles of PLCγ1 in endothelial biology
Chen D, Simons M. Emerging roles of PLCγ1 in endothelial biology. Science Signaling 2021, 14 PMID: 34344833, PMCID: PMC8507396, DOI: 10.1126/scisignal.abc6612.Peer-Reviewed Original ResearchConceptsUnique protein structurePhospholipase C-γ1Receptor tyrosine kinasesRole of PLCγ1Major physiological roleMolecular functionsDistinct vascular phenotypePLC familyC-γ1Signal transducerProtein structureDirect effectorTyrosine kinaseMembrane lipidsSecond messengerFunction mutationsPhysiological rolePLCγ1Endothelial biologyEndothelial cancerCritical roleVascular phenotypeEndothelial cellsKinaseFuture investigations
2023
Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/Src
Sjöberg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love D, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L. Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/Src. Journal Of Clinical Investigation 2023, 133: e161366. PMID: 37651195, PMCID: PMC10575733, DOI: 10.1172/jci161366.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseRenal cell carcinomaAnti-tumor immunityVascular leakageT cellsEndothelial barrierClear cell renal cell carcinomaCell renal cell carcinomaRegulatory T cellsHelper T cellsNitric oxide synthaseImmune cell activationAntitumor immunityImmunosuppressive cytokinesPoor prognosisCell carcinomaPLCγ pathwayOxide synthaseVascular permeabilityB cellsActivation of PLCγCell activationTumor vesselsDecreased expressionCancer forms
2018
Reprogramming the Endocardium
Chen D, Simons M. Reprogramming the Endocardium. Circulation Research 2018, 122: 913-915. PMID: 29599272, PMCID: PMC5880288, DOI: 10.1161/circresaha.118.312810.Peer-Reviewed Original Research