Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field
Wang X, Chen D, Chen K, Jubran A, Ramirez A, Astrof S. Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field. Developmental Biology 2016, 421: 108-117. PMID: 27955943, PMCID: PMC5221477, DOI: 10.1016/j.ydbio.2016.12.010.Peer-Reviewed Original ResearchFibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner
Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S. Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner. Developmental Biology 2015, 407: 195-210. PMID: 26434918, PMCID: PMC5312697, DOI: 10.1016/j.ydbio.2015.09.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBranchial RegionCardiovascular SystemCell LineageEmbryo, MammalianFemaleFibronectinsIntegrin alpha5beta1LIM-Homeodomain ProteinsMice, KnockoutModels, BiologicalMorphogenesisMutationNeural CrestOrgan SpecificityPharynxPhenotypePregnancySignal TransductionStem CellsT-Box Domain ProteinsThymus GlandTranscription FactorsConceptsPharyngeal arch arteriesCardiovascular developmentIntegrin α5Pharyngeal arch mesodermCell type-specific mannerCell typesMid-gestation lethalityType-specific mannerDistinct cell typesCardiac outflow tractMorphogenetic defectsPharyngeal regionMouse embryogenesisConditional mutantsExtracellular matrix glycoproteinEmbryonic developmentMutagenesis studiesCardiovascular morphogenesisNeural crestPAA formationSurface ectodermDefective formationArch arteriesFN1Matrix glycoprotein