2011
First Step in Folding of Nonconstitutive Membrane Proteins: Spontaneous Insertion of a Polypeptide into a Lipid Bilayer and Formation of Helical Structure
Karabadzhak A, Weerakkody D, Thakur M, Anderson M, Engelman D, Andreev O, Markin V, Reshetnyak Y. First Step in Folding of Nonconstitutive Membrane Proteins: Spontaneous Insertion of a Polypeptide into a Lipid Bilayer and Formation of Helical Structure. Biophysical Journal 2011, 100: 346a. DOI: 10.1016/j.bpj.2010.12.2088.Peer-Reviewed Original Research
1981
The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis
Engelman D, Steitz T. The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis. Cell 1981, 23: 411-422. PMID: 7471207, DOI: 10.1016/0092-8674(81)90136-7.Peer-Reviewed Original ResearchConceptsMembrane proteinsSecreted proteinsIntegral membrane proteinsHydrophobic leader peptideSecretion of proteinsHelical hairpinSpecific membrane receptorsPolypeptide sequenceSecond helixLeader peptideTransport proteinsLipid environmentTerminal helixN-terminusSpontaneous insertionMembrane receptorsHairpin structurePolypeptide structureProteinHelixHairpinHydrophobic interiorOnly alphaNonpolar sequencesHydrophobic portion