2017
Mortality, Length of Stay, and Cost Implications of Procedural Bleeding After Percutaneous Interventions Using Large-Bore Catheters
Redfors B, Watson BM, McAndrew T, Palisaitis E, Francese DP, Razavi M, Safirstein J, Mehran R, Kirtane AJ, Généreux P. Mortality, Length of Stay, and Cost Implications of Procedural Bleeding After Percutaneous Interventions Using Large-Bore Catheters. JAMA Cardiology 2017, 2: 798-802. PMID: 28315573, PMCID: PMC5815083, DOI: 10.1001/jamacardio.2017.0265.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBlood TransfusionCardiac CathetersCase-Control StudiesCohort StudiesDatabases, FactualEndovascular ProceduresFemaleHealth Care CostsHeart-Assist DevicesHematomaHospital MortalityHumansIncidenceLength of StayLinear ModelsMaleMiddle AgedMortalityMultivariate AnalysisPostoperative HemorrhagePrognosisProsthesis ImplantationReoperationRetrospective StudiesTranscatheter Aortic Valve ReplacementUnited StatesConceptsLength of stayLarge-bore cathetersHealth care costsNational Inpatient Sample databaseTotal health care costsCare costsTranscatheter interventionsMedian total health care costsUtilization Project National Inpatient Sample databaseHigh mortalityPercutaneous left ventricular assist deviceTranscatheter aortic valve replacementLeft ventricular assist deviceLonger hospital stayAortic valve replacementRetrospective cohort studyEndovascular aneurysm repairMultivariable logistic regressionMultivariable linear regressionPercutaneous transcatheter interventionsVentricular assist deviceHospital mortalityProcedural bleedingHospital stayValve replacement
2016
Relation Between Platelet Count and Platelet Reactivity to Thrombotic and Bleeding Risk: From the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents Study
Giustino G, Kirtane AJ, Généreux P, Baber U, Witzenbichler B, Neumann FJ, Weisz G, Maehara A, Rinaldi MJ, Metzger C, Henry TD, Cox DA, Duffy PL, Mazzaferri EL, Brodie BR, Stuckey TD, Dangas GD, Francese DP, Litherland C, Mehran R, Stone GW. Relation Between Platelet Count and Platelet Reactivity to Thrombotic and Bleeding Risk: From the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents Study. The American Journal Of Cardiology 2016, 117: 1703-1713. PMID: 27067621, DOI: 10.1016/j.amjcard.2016.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood PlateletsCause of DeathCoronary ThrombosisDose-Response Relationship, DrugDrug Therapy, CombinationDrug-Eluting StentsFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPlatelet CountPostoperative HemorrhageProspective StudiesRisk FactorsSurvival RateTreatment OutcomeUnited StatesConceptsDrug-Eluting Stents studyDual antiplatelet therapyPlatelet countHigher platelet countsDrug-eluting stentsPlatelet reactivityAntiplatelet therapyMultivariable adjustmentThrombotic complicationsStent studiesHigh riskCoronary artery implantationResidual platelet reactivitySimple hematological parametersSpontaneous myocardial infarctionLow platelet countBleeding riskCause mortalityDES implantationCrude riskPlatelet inhibitionHemorrhagic riskRisk stratificationStudy cohortThrombotic events
2015
Incidence, Predictors, and Impact of Post-Discharge Bleeding After Percutaneous Coronary Intervention
Généreux P, Giustino G, Witzenbichler B, Weisz G, Stuckey TD, Rinaldi MJ, Neumann FJ, Metzger DC, Henry TD, Cox DA, Duffy PL, Mazzaferri E, Yadav M, Francese DP, Palmerini T, Kirtane AJ, Litherland C, Mehran R, Stone GW. Incidence, Predictors, and Impact of Post-Discharge Bleeding After Percutaneous Coronary Intervention. Journal Of The American College Of Cardiology 2015, 66: 1036-1045. PMID: 26314532, DOI: 10.1016/j.jacc.2015.06.1323.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCoronary Artery DiseaseDose-Response Relationship, DrugDrug Administration ScheduleDrug-Eluting StentsFollow-Up StudiesHumansMiddle AgedMultivariate AnalysisPatient DischargePercutaneous Coronary InterventionPlatelet AggregationPlatelet Aggregation InhibitorsPostoperative CarePostoperative HemorrhagePredictive Value of TestsProportional Hazards ModelsProspective StudiesRadiographyRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsPost-discharge bleedingPost-discharge myocardial infarctionPercutaneous coronary interventionSuccessful percutaneous coronary interventionADAPT-DES studyCause mortalityCoronary interventionChronic oral anticoagulation therapyDrug-eluting stent implantationCox proportional hazards regressionLower baseline hemoglobinSuccessful DES implantationUnrestricted patient populationOral anticoagulation therapyLow platelet reactivityProportional hazards regressionHigher crude ratesBaseline hemoglobinHospital survivorsAnticoagulation therapyGastrointestinal bleedingDES implantationHospital dischargeMultivariable adjustmentPrognostic impactThe association between the extent of coronary artery disease and major bleeding events after percutaneous coronary intervention: from the ACUITY trial.
Madhavan MV, Généreux P, Palmerini T, Caixeta A, Xu K, McAndrew TC, Francese DP, Kirtane AJ, Mehran R, Stone GW. The association between the extent of coronary artery disease and major bleeding events after percutaneous coronary intervention: from the ACUITY trial. Journal Of Invasive Cardiology 2015, 27: 203-11. PMID: 25840404.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseFemaleHumansMaleMiddle AgedMulticenter Studies as TopicMultivariate AnalysisPercutaneous Coronary InterventionPostoperative HemorrhageProportional Hazards ModelsProspective StudiesRandomized Controlled Trials as TopicRisk FactorsConceptsNon-ST segment elevation acute coronary syndromesPercutaneous coronary interventionCoronary artery diseaseExtent of CADMajor bleeding ratesSYNTAX scoreACUITY trialMajor bleedingCoronary interventionArtery diseaseBleeding rateSegment elevation acute coronary syndromesSeverity of CADElevation acute coronary syndromeSevere coronary artery diseaseAdverse ischemic eventsMajor bleeding eventsAcute coronary syndromeCommon risk factorsRecurrent adverse eventsBleeding eventsPCI cohortSS tertilesCoronary syndromeHemorrhagic events