2016
Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions Involving Large Side Branches Outcomes From the Tryton Confirmatory Study
Généreux P, Kumsars I, Schneider JE, Lesiak M, Redfors B, Cornelis K, Selmon MR, Dens J, Hoye A, Metzger DC, Muyldermans L, Slagboom T, Francese DP, Ayele GM, Laak LL, Bartorelli AL, Cutlip DE, Kaplan AV, Leon MB. Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions Involving Large Side Branches Outcomes From the Tryton Confirmatory Study. JACC Cardiovascular Interventions 2016, 9: 1338-1346. PMID: 27388820, DOI: 10.1016/j.jcin.2016.03.042.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBiomarkersChromium AlloysCoronary AngiographyCoronary Artery DiseaseCoronary StenosisCoronary VesselsCreatine Kinase, MB FormEuropeFemaleHumansMaleMiddle AgedMyocardial InfarctionProspective StudiesProsthesis DesignRisk FactorsStentsTime FactorsTreatment OutcomeUnited StatesConceptsTryton Side Branch StentPeriprocedural myocardial infarctionSide Branch StentPivotal RCTsLarge side branchesPrimary endpointMyocardial infarctionBranch StentConfirmatory studiesBifurcation lesionsSide branchesProvisional side branchDedicated bifurcation stentsStent armOnly patientsAngiographic parametersCoronary artery bifurcationsPatientsRCTsSmall side branchesInfarctionOverall trialBifurcation stentsArtery bifurcationPre-defined performance goal
2015
Outcomes of a dedicated stent in coronary bifurcations with large side branches: A subanalysis of the randomized TRYTON bifurcation study
Généreux P, Kini A, Lesiak M, Kumsars I, Fontos G, Slagboom T, Ungi I, Metzger DC, Wykrzykowska JJ, Stella PR, Bartorelli AL, Fearon WF, Lefèvre T, Feldman RL, Tarantini G, Bettinger N, Minalu Ayele G, LaSalle L, Francese DP, Onuma Y, Grundeken MJ, Garcia-Garcia HM, Laak LL, Cutlip DE, Kaplan AV, Serruys PW, Leon MB. Outcomes of a dedicated stent in coronary bifurcations with large side branches: A subanalysis of the randomized TRYTON bifurcation study. Catheterization And Cardiovascular Interventions 2015, 87: 1231-1241. PMID: 26397982, DOI: 10.1002/ccd.26240.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery DiseaseCoronary StenosisCoronary ThrombosisFemaleHumansMaleMiddle AgedMyocardial InfarctionProspective StudiesProsthesis DesignRisk FactorsSeverity of Illness IndexSingle-Blind MethodStentsTime FactorsTreatment OutcomeConceptsPrimary end pointPercent diameter stenosisLarge side branchesBifurcation lesionsEnd pointDiameter stenosisMyocardial infarctionSegment percent diameter stenosisPeri-procedural myocardial infarctionAngiographic percent diameter stenosisSide branchesProvisional groupTarget vessel failureTarget vessel revascularizationTrue bifurcation lesionsComplex bifurcation lesionsNon-inferiority marginProvisional stenting strategyPrimary endpointVessel revascularizationTrial cohortCardiac deathTreatment strategiesProvisional stentingSB diameterA Randomized Trial of a Dedicated Bifurcation Stent Versus Provisional Stenting in the Treatment of Coronary Bifurcation Lesions
Généreux P, Kumsars I, Lesiak M, Kini A, Fontos G, Slagboom T, Ungi I, Metzger DC, Wykrzykowska JJ, Stella PR, Bartorelli AL, Fearon WF, Lefèvre T, Feldman RL, LaSalle L, Francese DP, Onuma Y, Grundeken MJ, Garcia-Garcia HM, Laak LL, Cutlip DE, Kaplan AV, Serruys PW, Leon MB. A Randomized Trial of a Dedicated Bifurcation Stent Versus Provisional Stenting in the Treatment of Coronary Bifurcation Lesions. Journal Of The American College Of Cardiology 2015, 65: 533-543. PMID: 25677311, DOI: 10.1016/j.jacc.2014.11.031.Peer-Reviewed Original ResearchConceptsTarget vessel failureTrue bifurcation lesionsCoronary bifurcation lesionsBifurcation lesionsProvisional stentingStent groupDiameter stenosisPre-specified noninferiority marginSegment percent diameter stenosisTrue coronary bifurcation lesionsProvisional groupSecondary angiographic endpointsSegment diameter stenosisSymptomatic coronary diseaseBinary restenosis rateMyocardial infarction rateSide branchesPercutaneous coronary interventionPercent diameter stenosisBifurcation coronary lesionsDedicated bifurcation stentsAngiographic cohortInfarction ratePrimary endpointCoronary intervention
2014
Clinical profile and impact of family history of premature coronary artery disease on clinical outcomes of patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction: analysis from the HORIZONS-AMI Trial
Ertelt K, Généreux P, Mintz GS, Brener SJ, Kirtane AJ, McAndrew TC, Francese DP, Ben-Yehuda O, Mehran R, Stone GW. Clinical profile and impact of family history of premature coronary artery disease on clinical outcomes of patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction: analysis from the HORIZONS-AMI Trial. Cardiovascular Revascularization Medicine 2014, 15: 375-380. PMID: 25288517, DOI: 10.1016/j.carrev.2014.09.002.Peer-Reviewed Original ResearchConceptsPremature coronary artery diseaseST-elevation myocardial infarctionPrimary percutaneous coronary interventionCoronary artery diseaseHORIZONS-AMI trialPercutaneous coronary interventionFamily historyCoronary interventionArtery diseaseIndependent predictorsClinical outcomesClinical profileMyocardial infarctionFinal TIMI 3 flowMyocardial blush grade 2Less diabetes mellitusTIMI 3 flowFuture cardiovascular eventsPrognosis of patientsShorter symptom onsetMore dyslipidemiaCardiovascular eventsCurrent smokersSymptom onsetDiabetes mellitus