Individual Patient Data Pooled Analysis of Randomized Trials of Bivalirudin versus Heparin in Acute Myocardial Infarction: Rationale and Methodology
Bikdeli B, McAndrew T, Crowley A, Chen S, Mehdipoor G, Redfors B, Liu Y, Zhang Z, Liu M, Zhang Y, Francese DP, Erlinge D, James SK, Han Y, Li Y, Kastrati A, Schüpke S, Stables RH, Shahzad A, Steg PG, Goldstein P, Frigoli E, Mehran R, Valgimigli M, Stone GW. Individual Patient Data Pooled Analysis of Randomized Trials of Bivalirudin versus Heparin in Acute Myocardial Infarction: Rationale and Methodology. Thrombosis And Haemostasis 2019, 120: 348-362. PMID: 31820428, PMCID: PMC7040882, DOI: 10.1055/s-0039-1700872.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnticoagulantsData Interpretation, StatisticalDatabases, FactualDrug Administration ScheduleHeparinHirudinsHumansMedical InformaticsMyocardial InfarctionOutcome Assessment, Health CarePeptide FragmentsPercutaneous Coronary InterventionRandomized Controlled Trials as TopicRecombinant ProteinsRiskTreatment OutcomeConceptsPercutaneous coronary interventionAcute myocardial infarctionMyocardial infarctionIndividual patient databaseProlonged bivalirudin infusionSegment elevation MIIndividual patient dataPatient-level dataDifferent relative risksConsensus-based definitionBivalirudin infusionPeriprocedural anticoagulationAnticoagulation regimenCoronary interventionElevation MIFemoral accessRandomized trialsPatient groupOutcome definitionsRelative riskPrespecified criteriaBivalirudinTrial publicationsST segmentPatient database