2016
Two-year outcomes after percutaneous coronary intervention of calcified lesions with drug-eluting stents
Généreux P, Redfors B, Witzenbichler B, Arsenault MP, Weisz G, Stuckey TD, Rinaldi MJ, Neumann FJ, Metzger D, Henry TD, Cox DA, Duffy PL, Mazzaferri EL, Francese DP, Marquis-Gravel G, Mintz GS, Kirtane AJ, Maehara A, Mehran R, Stone GW. Two-year outcomes after percutaneous coronary intervention of calcified lesions with drug-eluting stents. International Journal Of Cardiology 2016, 231: 61-67. PMID: 28040289, DOI: 10.1016/j.ijcard.2016.12.150.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDrug-eluting stentsPlatelet reactivityCoronary interventionIndependent predictorsDES PCILow residual platelet reactivityMajor adverse cardiac eventsSuccessful percutaneous coronary interventionContemporary percutaneous coronary interventionMultivariable logistic regression analysisCox proportional hazards modelDES generationADAPT-DES studyResidual platelet reactivityTarget lesion calcificationAdverse cardiac eventsPeripheral artery diseaseTwo-Year OutcomesKaplan-Meier curvesInsulin-treated diabetesCoronary arterial calcificationProportional hazards modelLogistic regression analysisAssociation of calcificationAngiographic predictors of 2‐year stent thrombosis in patients receiving drug‐eluting stents: Insights from the ADAPT‐DES study
Généreux P, Redfors B, Witzenbichler B, Maehara A, Yadav M, Weisz G, Francese DP, Parvataneni R, Brener SJ, Mehran R, Kirtane AJ, Stone GW. Angiographic predictors of 2‐year stent thrombosis in patients receiving drug‐eluting stents: Insights from the ADAPT‐DES study. Catheterization And Cardiovascular Interventions 2016, 89: 26-35. PMID: 26813732, DOI: 10.1002/ccd.26409.Peer-Reviewed Original ResearchMeSH KeywordsAgedCase-Control StudiesCoronary AngiographyCoronary Artery DiseaseCoronary ThrombosisDrug Therapy, CombinationDrug-Eluting StentsFemaleGermanyHumansMaleMiddle AgedMultivariate AnalysisPercutaneous Coronary InterventionPlatelet ActivationPlatelet Aggregation InhibitorsPlatelet Function TestsPredictive Value of TestsProportional Hazards ModelsProspective StudiesRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsADAPT-DES studyPercutaneous coronary interventionPresence of thrombusStent thrombosisDrug-eluting stentsAngiographic predictorsCardiology/American Heart Association type C lesionsCases of STIndependent angiographic core laboratoryIndex percutaneous coronary interventionMulticenter ADAPT-DES studyMultivariable Cox regression modelsSuccessful percutaneous coronary interventionDetailed angiographic analysisLong target lesionPre-specified analysisType C lesionsAcademic Research ConsortiumSaphenous vein graftsCox regression modelAngiographic core laboratoryADAPT-DESAngiographic variablesCoronary interventionSevere calcification
2015
Incidence, Predictors, and Impact of Post-Discharge Bleeding After Percutaneous Coronary Intervention
Généreux P, Giustino G, Witzenbichler B, Weisz G, Stuckey TD, Rinaldi MJ, Neumann FJ, Metzger DC, Henry TD, Cox DA, Duffy PL, Mazzaferri E, Yadav M, Francese DP, Palmerini T, Kirtane AJ, Litherland C, Mehran R, Stone GW. Incidence, Predictors, and Impact of Post-Discharge Bleeding After Percutaneous Coronary Intervention. Journal Of The American College Of Cardiology 2015, 66: 1036-1045. PMID: 26314532, DOI: 10.1016/j.jacc.2015.06.1323.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCoronary Artery DiseaseDose-Response Relationship, DrugDrug Administration ScheduleDrug-Eluting StentsFollow-Up StudiesHumansMiddle AgedMultivariate AnalysisPatient DischargePercutaneous Coronary InterventionPlatelet AggregationPlatelet Aggregation InhibitorsPostoperative CarePostoperative HemorrhagePredictive Value of TestsProportional Hazards ModelsProspective StudiesRadiographyRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsPost-discharge bleedingPost-discharge myocardial infarctionPercutaneous coronary interventionSuccessful percutaneous coronary interventionADAPT-DES studyCause mortalityCoronary interventionChronic oral anticoagulation therapyDrug-eluting stent implantationCox proportional hazards regressionLower baseline hemoglobinSuccessful DES implantationUnrestricted patient populationOral anticoagulation therapyLow platelet reactivityProportional hazards regressionHigher crude ratesBaseline hemoglobinHospital survivorsAnticoagulation therapyGastrointestinal bleedingDES implantationHospital dischargeMultivariable adjustmentPrognostic impact