2021
Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures as Clinical Trial Endpoints: Experience from a Multicenter Pragmatic Trial in Children with Crohn’s Disease
Miller T, Schuchard J, Carle A, Forrest C, Kappelman M, Group T, Adler J, Ammoury R, Bass D, Bass J, Benkov K, Bousvaros A, Boyle B, Cabrera J, Colletti R, Dorsey J, Ebach D, Firestine A, Gulati A, Hoffenberg E, Jester T, Kaplan J, Kugathasan S, Kusek M, Leibowitz I, Linville T, Margolis P, Minar P, Rios Z, Moses J, Palomo P, Pappa H, Pashankar D, Saeed S, Samson C, Sandberg K, Steiner S, Strople J, Sullivan J, Tung J, Wali P. Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures as Clinical Trial Endpoints: Experience from a Multicenter Pragmatic Trial in Children with Crohn’s Disease. The Journal Of Pediatrics 2021, 242: 86-92.e3. PMID: 34740588, PMCID: PMC8882140, DOI: 10.1016/j.jpeds.2021.10.053.Peer-Reviewed Original ResearchConceptsPROMIS pediatric measuresMulticenter pragmatic trialCrohn's diseasePediatric measuresClinical trialsDisease activityPain interferencePragmatic trialPediatric patient-reported outcome measuresPatient-reported outcome measuresLower PRO scoresOutcomes Measurement Information System (PROMIS) pediatric measuresPRO score changesSteroid-free remissionPediatric Crohn's diseaseChronic pediatric illnessPragmatic clinical trialsClinical trial endpointsUse of patientPediatric patientsStudy endpointClinical outcomesPRO scoresTrial endpointsPRO endpoints
2020
Continued Statural Growth in Older Adolescents and Young Adults With Crohn’s Disease and Ulcerative Colitis Beyond the Time of Expected Growth Plate Closure
Gupta N, Liu C, King E, Sylvester F, Lee D, Boyle B, Trauernicht A, Chen S, Colletti R, Adler J, Ali S, Al-Nimr A, Ayers T, Baron H, Beasley G, Benkov K, Cabrera J, Cho-Dorado M, Dancel L, Di Palma J, Dorsey J, Gulati A, Hellmann J, Higuchi L, Hoffenberg E, Israel E, Jester T, Kiparissi F, Konikoff M, Leibowitz I, Maheshwari A, Moulton D, Moses J, Ogunmola N, Palmadottir J, Pandey A, Pappa H, Pashankar D, Pasternak B, Patel A, Quiros J, Rountree C, Samson C, Sandberg K, Schoen B, Steiner S, Stephens M, Sudel B, Sullivan J, Suskind D, Tomer G, Tung J, Verstraete S. Continued Statural Growth in Older Adolescents and Young Adults With Crohn’s Disease and Ulcerative Colitis Beyond the Time of Expected Growth Plate Closure. Inflammatory Bowel Diseases 2020, 26: 1880-1889. PMID: 31968095, DOI: 10.1093/ibd/izz334.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseGrowth plate closureUlcerative colitisCrohn's diseaseAge 15 yearsPlate closureStatural growthHeight gainNutrition Examination SurveyFinal adult heightHeight velocity curvesTotal height gainBowel diseasePediatric patientsExamination SurveyPatient transitionsNational HealthAdult carePatientsDisease statusAdult heightDiseaseYoung adultsGrowth plateRadiographic closure
2014
Histopathology of Duodenal Mucosal Lesions in Pediatric Patients with Inflammatory Bowel Disease: Statistical Analysis to Identify Distinctive Features
Hardee S, Alper A, Pashankar DS, Morotti RA. Histopathology of Duodenal Mucosal Lesions in Pediatric Patients with Inflammatory Bowel Disease: Statistical Analysis to Identify Distinctive Features. Pediatric And Developmental Pathology 2014, 17: 450-454. PMID: 25207874, DOI: 10.2350/14-07-1529-oa.1.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal tractVillous bluntingIntraepithelial lymphocytesPediatric patientsDuodenal lesionsDifferent etiopathogenesisUlcerative colitisCrohn's diseaseInflammatory bowel disease patientsCases of duodenitisDuodenal mucosal lesionsBowel disease patientsInflammatory bowel diseasePresence of granulomasAge-matched controlsLamina propria eosinophilsKruskal-Wallis testingCeliac groupDuodenal pathologyDuodenitis casesAssociated gastritisBowel diseaseCrypt hyperplasiaMucosal lesionsPediatric population