Low Anti-Tumor Necrosis Factor Levels During Maintenance Phase Are Associated With Treatment Failure in Children With Crohn’s Disease
Moses J, Adler J, Saeed S, Firestine A, Galanko J, Ammoury R, Bass D, Bass J, Bastidas M, Benkov K, Bousvaros A, Cabrera J, Chun K, Dorsey J, Ebach D, Gulati A, Herfarth H, Ivanova A, Jester T, Kaplan J, Kusek M, Leibowitz I, Linville T, Margolis P, Minar P, Molle-Rios Z, Niklinska-Schirtz B, Olano K, Osaba L, Palomo P, Pashankar D, Pitch L, Samson C, Sandberg K, Steiner S, Strople J, Sullivan J, Tung J, Wali P, Wohl D, Zikry M, Boyle B, Kappelman M. Low Anti-Tumor Necrosis Factor Levels During Maintenance Phase Are Associated With Treatment Failure in Children With Crohn’s Disease. Inflammatory Bowel Diseases 2024, izae239. PMID: 39418336, DOI: 10.1093/ibd/izae239.Peer-Reviewed Original ResearchTherapeutic drug levelsPatients treated with adalimumabPatients treated with infliximabHigher drug levelsAnti-TNF levelsMedian drug levelsTreatment failureCombination therapyReduce treatment failureDrug levelsLD-MTXLow-dose oral methotrexateAssociated with treatment failureCrohn's diseaseMonotherapy to combination therapyRisk of treatment failureAnti-tumor necrosis factorEffects of combination therapyCombination therapy armMaintenance of remissionAssociated with reduced riskPediatric Crohn's diseasePost hoc analysisAdalimumab initiationMaintenance therapyHigh Body Mass Index and Response to Anti-Tumor Necrosis Factor Therapy in Pediatric Crohn’s Disease
Ebach D, Jester T, Galanko J, Firestine A, Ammoury R, Cabrera J, Bass J, Minar P, Olano K, Margolis P, Sandberg K, Linnville T, Kaplan J, Pitch L, Steiner S, Bass D, Moses J, Adler J, Gulati A, Wali P, Pashankar D, Ivanova A, Herfarth H, Wohl D, Benkov K, Strople J, Sullivan J, Tung J, Molle-Rios Z, Saeed S, Bousvaros A, Kappelman M. High Body Mass Index and Response to Anti-Tumor Necrosis Factor Therapy in Pediatric Crohn’s Disease. The American Journal Of Gastroenterology 2024, 119: 1110-1116. PMID: 38445644, PMCID: PMC11150092, DOI: 10.14309/ajg.0000000000002741.Peer-Reviewed Original ResearchHigher body mass indexNormal body mass indexPediatric Crohn's diseaseBody mass indexAnti-TNF levelsInfliximab initiationTrough levelsTreatment failureObese patientsMass indexTime-to-treatment failureCrohn's diseaseResponse to anti-TNF therapyAssociated with treatment failureMonotherapy to combination therapyBody mass index groupsBody mass index categoriesPrescribed anti-TNFProactive drug monitoringAdalimumab-treated patientsDrug trough levelsAnti-TNF treatmentAnti-TNF therapyInfliximab trough levelsWeight-based dosing