Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In Vivo
Sasaki CT, Doukas SG, Doukas PG, Vageli DP. Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In Vivo. Cancers 2021, 13: 852. PMID: 33670587, PMCID: PMC7923205, DOI: 10.3390/cancers13040852.Peer-Reviewed Original ResearchAcidic bileBile acidsDeoxycholic acidUnconjugated secondary bile acidsDNA/RNA oxidative damageConjugated primary bile acidsUpper aerodigestive tractSecondary bile acidsPrimary bile acidsAlternative therapeutic strategiesPremalignant dysplastic lesionsHypopharyngeal carcinogenesisAntacid therapyRelevant molecular pathwaysRNA oxidative damageSimilar oncogenic effectsEsophageal refluxRefractory GERDAerodigestive tractDysplastic lesionsRisk factorsPremalignant lesionsBile contentTherapeutic strategiesP53 expression