2019
Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung
Djureinovic D, Pontén V, Landelius P, Al Sayegh S, Kappert K, Kamali-Moghaddam M, Micke P, Ståhle E. Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung. BMC Cancer 2019, 19: 741. PMID: 31357969, PMCID: PMC6664554, DOI: 10.1186/s12885-019-5943-3.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAgedBlood ProteinsCarcinoembryonic AntigenCarcinoma, Non-Small-Cell LungChemokines, CXCCohort StudiesData AccuracyEarly Detection of CancerFemaleGPI-Linked ProteinsHumansImmunoassayLung NeoplasmsMaleMass ScreeningModels, BiologicalReceptor, ErbB-3ROC CurveSensitivity and SpecificityStatistics, NonparametricVascular Endothelial Growth Factor Receptor-2ConceptsNon-small cell lung cancerProximity extension assayLung adenocarcinomaLung diseaseDisease groupNon-malignant lung diseasesEarly lung cancer detectionCell lung cancerDifferent lung diseasesDifferent plasma levelsMultiplex proximity extension assayHigh clinical relevanceNovel protein markersDifferent plasma concentrationsLocalized diseaseOverall prognosisSurgical resectionNSCLC patientsLung metastasesColorectal cancerLung cancerPlasma levelsTypical carcinoidLung conditionsLAC patients
2018
An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1–Positive Lung Adenocarcinomas
Miyashita N, Horie M, Suzuki H, Yoshihara M, Djureinovic D, Persson J, Brunnström H, Lindskog C, Elfving H, Micke P, Saito A, Nagase T. An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1–Positive Lung Adenocarcinomas. Journal Of Thoracic Oncology 2018, 13: 1676-1691. PMID: 30121393, DOI: 10.1016/j.jtho.2018.07.096.Peer-Reviewed Original ResearchConceptsAchaete-scute family bHLH transcription factor 1Transcriptome profilingGenome-wide epigenetic profilingRecent transcriptome profilingGenome-wide methylation analysisFamily bHLH transcription factor 1Cell cycle controlMaster transcriptional regulatorGene expression profilingGlobal DNA hypomethylationLung adenocarcinomaEpigenome featuresTranscription factor 1Transcriptional regulatorsTranscriptional programsCancer Genome AtlasEpigenetic profilingLung adenocarcinoma cellsMolecular featuresExpression profilingCycle controlDNA hypomethylationIntegrative analysisMethylation analysisCell death ligand-1 (PD-L1) protein expression