2020
Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
Arnsten AFT, Datta D, Del Tredici K, Braak H. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & Dementia 2020, 17: 115-124. PMID: 33075193, PMCID: PMC7983919, DOI: 10.1002/alz.12192.Peer-Reviewed Original ResearchConceptsAbnormal tau phosphorylationTau pathologyProjection neuronsTau phosphorylationAssociation cortexAlzheimer's diseaseBrain tau pathologySporadic Alzheimer's diseaseSusceptible microenvironmentCalcium dysregulationVulnerable neuronsAβ plaquesAβ productionSporadic formsSAD pathologyRhesus monkeysAbnormal phosphorylationPathological eventsDiseaseAβ oligomersPathologyNeuronsVicious cycleCortexTau
2016
Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia
Datta D, Arion D, Roman K, Volk D, Lewis D. Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia. American Journal Of Psychiatry 2016, 174: 163-171. PMID: 27523502, PMCID: PMC5288270, DOI: 10.1176/appi.ajp.2016.16020204.Peer-Reviewed Original ResearchConceptsLayer 3 pyramidal cellsDorsolateral prefrontal cortexPyramidal cellsParvalbumin interneuronsGray matterExcessive dopamine releaseDendritic spine densityCortical pyramidal cellsCommon final pathwayStriatal hyperdopaminergiaDLPFC gray matterVentral mesencephalonSpine deficitsSpine lossSpine densityExcitatory projectionsCognitive dysfunctionPairs of schizophreniaDopamine cellsDopamine releaseDendritic spinesComparison subjectsFinal pathwaySubcortical hyperdopaminergiaPrefrontal cortex
2015
Reciprocal Alterations in Regulator of G Protein Signaling 4 and microRNA16 in Schizophrenia
Kimoto S, Glausier J, Fish K, Volk D, Bazmi H, Arion D, Datta D, Lewis D. Reciprocal Alterations in Regulator of G Protein Signaling 4 and microRNA16 in Schizophrenia. Schizophrenia Bulletin 2015, 42: 396-405. PMID: 26424323, PMCID: PMC4753606, DOI: 10.1093/schbul/sbv139.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsDorsolateral prefrontal cortexG Protein Signaling 4Schizophrenia subjectsRGS4 mRNANMDAR hypofunctionNMDAR activityProtein levelsN-methyl-D-aspartate (NMDA) receptor hypofunctionRole of RGS4Pathology of schizophreniaHealthy comparison subjectsRGS4 mRNA levelsLevels of miR16RGS4 levelsProtein-coupled receptorsPyramidal neuronsReceptor hypofunctionPyramidal cellsComparison subjectsIncreased expressionHypofunctionPrefrontal cortexSchizophreniaMRNA levelsAltered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia
Datta D, Arion D, Corradi J, Lewis D. Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia. Biological Psychiatry 2015, 78: 775-785. PMID: 25981171, PMCID: PMC4600637, DOI: 10.1016/j.biopsych.2015.03.030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsBenzodiazepinesCdc42 GTP-Binding ProteinCytoskeletal ProteinsFemaleGene Expression RegulationGTP-Binding Protein RegulatorsHaloperidolHumansLaser Capture MicrodissectionLim KinasesMacaca fascicularisMaleMiddle AgedOlanzapineP21-Activated KinasesPrefrontal CortexRho GTP-Binding ProteinsRho Guanine Nucleotide Dissociation Inhibitor alphaRNA-Binding ProteinsSchizophreniaSignal TransductionConceptsSerine/threonine protein kinaseThreonine protein kinaseActin cytoskeletonProtein kinaseCdc42 effector proteinsCell type-specific fashionMessenger RNA levelsCell division cycle 42Altered expressionType-specific fashionDLPFC gray matterRNA levelsEffector proteinsActin dynamicsPathway componentsSame transcriptKey organizerMessenger RNALaser microdissectionSynergistic alterationsCdc42CytoskeletonQuantitative polymerase chain reactionSpine formationKinaseDistinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder
Arion D, Corradi J, Tang S, Datta D, Boothe F, He A, Cacace A, Zaczek R, Albright C, Tseng G, Lewis D. Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder. Molecular Psychiatry 2015, 20: 1397-1405. PMID: 25560755, PMCID: PMC4492919, DOI: 10.1038/mp.2014.171.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnimalsAntipsychotic AgentsFemaleGene Expression ProfilingGene Expression RegulationHumansLaser Capture MicrodissectionMacaca fascicularisMaleMiddle AgedMitochondrial ProteinsOligonucleotide Array Sequence AnalysisPrefrontal CortexPsychotic DisordersPyramidal CellsRNA, MessengerSchizophreniaSignal TransductionTranscriptomeUbiquitin
2012
Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients
Harberts E, Datta D, Chen S, Wohler J, Oh U, Jacobson S. Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients. Journal Of Neuroimmune Pharmacology 2012, 8: 51-57. PMID: 22956240, PMCID: PMC4765953, DOI: 10.1007/s11481-012-9397-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdultBiomarkersBrainCell SeparationFemaleHumansIsoquinolinesLeukocytes, MononuclearLipopolysaccharide ReceptorsMagnetic Resonance ImagingMaleMembrane Potential, MitochondrialMiddle AgedMitochondriaMultiple SclerosisPositron-Emission TomographyProtein BindingPyridinesRadioligand AssayRadiopharmaceuticalsReal-Time Polymerase Chain ReactionReceptors, GABAConceptsPeripheral blood mononuclear cellsMultiple sclerosis patientsExpression of TSPOMagnetic resonance imagingPositron emission tomographyTSPO expressionSclerosis patientsCentral nervous system inflammationHealthy donor cohortNervous system inflammationMarkers of inflammationPotential peripheral biomarkerBlood mononuclear cellsTranslocator protein 18TSPO protein expressionSystem inflammationMS patientsNeuroinflammatory conditionsPeripheral biomarkersMononuclear cellsNeuropathologic conditionsDonor cohortInflammatory diseasesHealthy donorsHealthy individuals