2016
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan Z, Kim E, Datta D, Lewis D, Soderling S. Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? Journal Of Neuroscience 2016, 36: 11411-11417. PMID: 27911743, PMCID: PMC5125208, DOI: 10.1523/jneurosci.2360-16.2016.Peer-Reviewed Original ResearchConceptsMental disordersActivity-dependent modulationCritical neural pathwaysGenetic risk allelesExcitatory synapsesNeurodevelopmental disturbancesNeural pathwaysBrain disordersSynaptic cytoskeletonRisk allelesDisordersNeurodevelopmental disordersActin dysregulationSpine structureConvergent mechanismsAutism spectrum disorderPostsynaptic complexSpectrum disorderPathwayActin cytoskeletonCandidate genesGenetic evidenceActin polymerizationAbnormalitiesSchizophrenia
2011
Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder
Campbell D, Datta D, Jones S, Batey Lee E, Sutcliffe J, Hammock E, Levitt P. Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder. Journal Of Neurodevelopmental Disorders 2011, 3: 101-112. PMID: 21484202, PMCID: PMC3113442, DOI: 10.1007/s11689-010-9071-2.Peer-Reviewed Original ResearchAutism spectrum disorderASD susceptibilitySocial behaviorGenetic association analysisSpectrum disorderGenetic variationOxytocin receptor gene variantsGenetic polymorphismsGenetic markersAssociation analysisLines of evidenceCommon genetic polymorphismsPhenotype domainsCore deficitBehavioral flexibilityOXTR polymorphismsPolymorphismOXTR geneGene variantsASD phenotypeSubset of familiesASD riskCurrent findingsLarge independent cohortsFunctional polymorphisms