2021
Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes
Woo E, Sansing LH, Arnsten AFT, Datta D. Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes. Chronic Stress 2021, 5: 24705470211029254. PMID: 34485797, PMCID: PMC8408896, DOI: 10.1177/24705470211029254.Peer-Reviewed Original ResearchLoss of spinesPrefrontal cortexSpine lossPersistent firingUncontrollable stressDendritic spine lossChronic stress exposureMarked cognitive impairmentInternal calcium releaseRecurrent excitatory connectionsCatecholamine releaseInflammatory signalingSynaptic connectivityCognitive disordersChronic exposureCalcium homeostasisPFC neuronsCognitive impairmentBrain regionsChronic stressCalcium releaseExcitatory connectionsStress exposurePotassium channelsSpine
2020
Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau
Leslie SN, Datta D, Christensen KR, van Dyck CH, Arnsten AFT, Nairn AC. Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. Frontiers In Aging Neuroscience 2020, 12: 576723. PMID: 33192469, PMCID: PMC7655962, DOI: 10.3389/fnagi.2020.576723.Peer-Reviewed Original ResearchFrontal association cortexAged ratsAlzheimer's diseaseAD tau pathologyAD-related sitesAge-related lossMemory-enhancing effectsLargest risk factorPhosphorylation of tauAge-related changesTau dissociationTau pathologyRisk factorsTau hyperphosphorylationFrontal cortexHealthy individualsTherapeutic targetAssociation cortexCognitive impairmentGEBR-7bBrain regionsRodent hippocampusPotassium channelsPhosphodiesterase 4DRats