Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan Z, Kim E, Datta D, Lewis D, Soderling S. Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? Journal Of Neuroscience 2016, 36: 11411-11417. PMID: 27911743, PMCID: PMC5125208, DOI: 10.1523/jneurosci.2360-16.2016.Peer-Reviewed Original ResearchConceptsMental disordersActivity-dependent modulationCritical neural pathwaysGenetic risk allelesExcitatory synapsesNeurodevelopmental disturbancesNeural pathwaysBrain disordersSynaptic cytoskeletonRisk allelesDisordersNeurodevelopmental disordersActin dysregulationSpine structureConvergent mechanismsAutism spectrum disorderPostsynaptic complexSpectrum disorderPathwayActin cytoskeletonCandidate genesGenetic evidenceActin polymerizationAbnormalitiesSchizophreniaLayer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia
Hoftman G, Datta D, Lewis D. Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia. Biological Psychiatry 2016, 81: 862-873. PMID: 27455897, PMCID: PMC5136518, DOI: 10.1016/j.biopsych.2016.05.022.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexInhibitory gamma-aminobutyric acid (GABA) neuronsGamma-aminobutyric acid (GABA) neuronsPrefrontal cortexCertain clinical featuresExcitatory pyramidal neuronsAdverse environmental exposuresDisorders of neurodevelopmentNature of schizophreniaDLPFC circuitryInhibitory circuitryClinical featuresPyramidal neuronsDisease processDevelopmental refinementMemory impairmentMemory alterationsDevelopmental disturbancesNeural circuitrySchizophreniaEnvironmental exposuresLate developmental processesNeurodevelopmental disordersSpecific populationsAlterations