2016
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan Z, Kim E, Datta D, Lewis D, Soderling S. Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? Journal Of Neuroscience 2016, 36: 11411-11417. PMID: 27911743, PMCID: PMC5125208, DOI: 10.1523/jneurosci.2360-16.2016.Peer-Reviewed Original ResearchConceptsMental disordersActivity-dependent modulationCritical neural pathwaysGenetic risk allelesExcitatory synapsesNeurodevelopmental disturbancesNeural pathwaysBrain disordersSynaptic cytoskeletonRisk allelesDisordersNeurodevelopmental disordersActin dysregulationSpine structureConvergent mechanismsAutism spectrum disorderPostsynaptic complexSpectrum disorderPathwayActin cytoskeletonCandidate genesGenetic evidenceActin polymerizationAbnormalitiesSchizophrenia
2015
Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia
Datta D, Arion D, Corradi J, Lewis D. Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia. Biological Psychiatry 2015, 78: 775-785. PMID: 25981171, PMCID: PMC4600637, DOI: 10.1016/j.biopsych.2015.03.030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsBenzodiazepinesCdc42 GTP-Binding ProteinCytoskeletal ProteinsFemaleGene Expression RegulationGTP-Binding Protein RegulatorsHaloperidolHumansLaser Capture MicrodissectionLim KinasesMacaca fascicularisMaleMiddle AgedOlanzapineP21-Activated KinasesPrefrontal CortexRho GTP-Binding ProteinsRho Guanine Nucleotide Dissociation Inhibitor alphaRNA-Binding ProteinsSchizophreniaSignal TransductionConceptsSerine/threonine protein kinaseThreonine protein kinaseActin cytoskeletonProtein kinaseCdc42 effector proteinsCell type-specific fashionMessenger RNA levelsCell division cycle 42Altered expressionType-specific fashionDLPFC gray matterRNA levelsEffector proteinsActin dynamicsPathway componentsSame transcriptKey organizerMessenger RNALaser microdissectionSynergistic alterationsCdc42CytoskeletonQuantitative polymerase chain reactionSpine formationKinase