Activation of autophagy in mesenchymal stem cells provides tumor stromal support
Sanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS, Pochampally RR. Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis 2011, 32: 964-972. PMID: 21317300, PMCID: PMC3128555, DOI: 10.1093/carcin/bgr029.Peer-Reviewed Original ResearchConceptsSD-MSCsStromal cellsMesenchymal stem cellsMultipotential mesenchymal stem cellsMCF-7 tumor growthBreast cancer cell proliferationStem cellsVivo tumor xenograftsMCF-7 breast cancer cellsCancer cell proliferationSolid tumor survivalBreast cancer cellsBeclin-1 stainingActivation of autophagyAnti-apoptotic factorsTime-dependent increaseUpregulation of autophagySolid tumor microenvironmentBreast cancerImmunodeficient miceTumor xenograftsSolid tumorsTumor growthParacrine factorsSurvival mechanism