2019
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.Peer-Reviewed Original ResearchConceptsBM transplantsDecidual cellsPregnancy lossMesenchymal stem cellsAdult bone marrow progenitorsDecidualization-related genesBone marrow progenitorsAdult bone marrowWT donorsPhysiologic contributionSuccessful pregnancyBMDC recruitmentStromal expansionImmune cellsEndometrial cellsDeficient miceUterine expressionUterine tissueDecidual stromaPregnancyBone marrowNonhematopoietic cellsBMDCsHemochorial placentaMarrow progenitors
2013
Very Small Embryonic‐Like Stem Cells from the Murine Bone Marrow Differentiate into Epithelial Cells of the Lung
Kassmer SH, Jin H, Zhang PX, Bruscia EM, Heydari K, Lee JH, Kim CF, Kassmer SH, Krause DS. Very Small Embryonic‐Like Stem Cells from the Murine Bone Marrow Differentiate into Epithelial Cells of the Lung. Stem Cells 2013, 31: 2759-2766. PMID: 23681901, PMCID: PMC4536826, DOI: 10.1002/stem.1413.Peer-Reviewed Original ResearchConceptsEpithelial cellsSmall embryonic-like stem cellsLung epithelial cellsEmbryonic-like stem cellsStem/progenitor cellsStem cellsDonor miceHematopoietic stem/progenitor cellsBM cellsAdult BMBone marrowSmall embryonicNonhematopoietic cellsProgenitor cellsBroad differentiation potentialVSELsEngraftmentLungHigh rateNumerous reportsAdult stem cellsDifferentiation potentialCellsFirst reportReport
2012
Nonhematopoietic Cells are the Primary Source of Bone Marrow‐Derived Lung Epithelial Cells
Kassmer SH, Bruscia EM, Zhang P, Krause DS. Nonhematopoietic Cells are the Primary Source of Bone Marrow‐Derived Lung Epithelial Cells. Stem Cells 2012, 30: 491-499. PMID: 22162244, PMCID: PMC3725285, DOI: 10.1002/stem.1003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial ProteinsBone Marrow CellsBone Marrow TransplantationCell SeparationEpithelial CellsGene ExpressionLuminescent ProteinsLungMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalPulmonary Surfactant-Associated Protein CRecombinant ProteinsSingle-Cell AnalysisConceptsLung epithelial cellsNonhematopoietic cellsBM cellsEpithelial cellsBone marrowLungs of miceType 2 pneumocytesNonhematopoietic stem cellsNonhematopoietic fractionAdult BMPrimitive stem cell populationNull miceProgenitor cellsMiceStem cell populationCell populationsMarrowStem cellsMultiple tissuesHematopoietic stemBMCellsPrevious studiesEngraftmentLung
2007
Lung‐specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation
Herzog EL, Van Arnam J, Hu B, Zhang J, Chen Q, Haberman AM, Krause DS. Lung‐specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation. The FASEB Journal 2007, 21: 2592-2601. PMID: 17449722, DOI: 10.1096/fj.06-7861com.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationChromosome DeletionFemaleInflammationIntercellular Signaling Peptides and ProteinsMaleMiceMice, KnockoutPeptidesPostoperative ComplicationsPulmonary Surfactant-Associated Protein CTransplantation ChimeraTransplantation ConditioningWhole-Body IrradiationY ChromosomeConceptsTransplanted bone marrow-derived cellsY chromosomeHeterokaryon formationBone marrow-derived cellsLung-specific gene expressionGene expression patternsSurfactant protein CY chromosome lossNuclear reprogrammingSP-C mRNAChromosome lossExpression patternsGene expressionCell fusionSP-C deficiencyChromosomesReprogrammingSpNonhematopoietic cellsWild-type marrowMarrow-derived cellsCellsProtein CProteinFusion
2005
Engraftment of Bone Marrow‐Derived Epithelial Cells
Krause DS. Engraftment of Bone Marrow‐Derived Epithelial Cells. Annals Of The New York Academy Of Sciences 2005, 1044: 117-124. PMID: 15958704, DOI: 10.1196/annals.1349.015.Peer-Reviewed Original ResearchConceptsBone marrow-derived cellsMarrow-derived cellsEpithelial cellsMarrow-derived epithelial cellsNonhematopoietic cellsLevel of engraftmentCell plasticityStem cell plasticityAllogeneic settingAdult stem cell plasticityBM cellsBuccal mucosaGastrointestinal tractBone marrowTissue damageEngraftmentFunctional epithelial cellsTherapeutic relevanceNonhematopoietic cell typesPrecursor cellsMost reportsDiseased organsLungMarrowDifferent phenotypes
2003
Plasticity of marrow-derived stem cells
Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003, 102: 3483-3493. PMID: 12893756, DOI: 10.1182/blood-2003-05-1664.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsStem cellsAdult stem cell plasticityMesenchymal stem cellsStem cell plasticityBone marrowMature blood cellsEndothelial cell progenitorsAdult bone marrowBone marrow subpopulationsMultiple mesenchymal tissuesCell plasticityMarrow-derived stem cellsCell progenitorsMarrow subpopulationsMultiple tissuesMature cellsConditions differentiationNeural cellsDifferentiationEpithelial cellsNonhematopoietic cellsTissue injuryGastrointestinal tractSkeletal muscle
1998
CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb.
Krause DS, Mucenski ML, Lawler AM, May WS. CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb. Experimental Hematology 1998, 26: 1086-92. PMID: 9766450.Peer-Reviewed Original ResearchConceptsC-MybDevelopmental hematopoiesisES cellsPromoter activityHematopoietic cellsD3 embryonic stem cellsStage-specific mannerES cell differentiationEmbryonic stem cellsPrimitive hematopoietic cellsDefinitive hematopoiesisBone marrow stemCell surface glycoproteinBlood islandsEmbryoid bodiesEndothelial cellsTransient transfectionCell differentiationEmbryosStem cellsProgenitor cellsYolk sacHematopoiesisNonhematopoietic cellsCD34 expression