Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells
Bleakley M, Heimfeld S, Jones LA, Turtle C, Krause D, Riddell SR, Shlomchik W. Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells. Transplantation And Cellular Therapy 2014, 20: 705-716. PMID: 24525279, PMCID: PMC3985542, DOI: 10.1016/j.bbmt.2014.01.032.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsHematopoietic cell transplantationMemory T cellsStem cell graftsT cellsCell graftsPathogen-specific memory T cellsPeripheral blood stem cell graftsAllogeneic stem cell graftsBlood stem cell graftsNaïve T cell subsetsAllogeneic hematopoietic cell transplantationFrequent major complicationCentral memory phenotypeT cell subsetsBlood stem cellsNaïve T cellsOpportunistic pathogenCommon opportunistic pathogenStem cellsHost diseaseHCT outcomesEffector cytokinesMajor complicationsMemory phenotype