Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit
He L, Cohen EB, Edwards APB, Xavier-Ferrucio J, Bugge K, Federman RS, Absher D, Myers RM, Kragelund BB, Krause DS, DiMaio D. Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit. IScience 2019, 17: 167-181. PMID: 31279934, PMCID: PMC6614117, DOI: 10.1016/j.isci.2019.06.027.Peer-Reviewed Original ResearchErythropoietin receptorPrimary human hematopoietic progenitor cellsProtein aptamerGrowth factor independenceHuman hematopoietic progenitor cellsJAK/STATMurine BaF3 cellsTransmembrane domainCellular processesCytoplasmic tyrosinesCytoplasmic domainHematopoietic progenitor cellsErythroid differentiationBaF3 cellsCommon subunitFactor independenceSerum withdrawalCell deathCooperative signalingEPO receptorEPOR homodimersProgenitor cellsEssential roleSubunitsSignaling