2020
Liver Pathologic Changes After Direct-Acting Antiviral Agent Therapy and Sustained Virologic Response in the Setting of Chronic Hepatitis C Virus Infection.
Celli R, Saffo S, Kamili S, Wiese N, Hayden T, Taddei T, Jain D. Liver Pathologic Changes After Direct-Acting Antiviral Agent Therapy and Sustained Virologic Response in the Setting of Chronic Hepatitis C Virus Infection. Archives Of Pathology & Laboratory Medicine 2020, 145: 419-427. PMID: 32810870, PMCID: PMC10960369, DOI: 10.5858/arpa.2020-0008-oa.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHCC developmentChronic hepatitis C virus (HCV) infectionChronic viral hepatitis C infectionHepatitis C virus infectionViral hepatitis C infectionTissue polymerase chain reactionAntiviral agent therapyLiver histologic findingsLiver pathologic changesNon-SVR groupOccult HCV infectionPersistent liver inflammationSuccessful DAA therapyC virus infectionHepatitis C infectionSubset of patientsDegree of inflammationNumber of patientsPresence of virusDAA therapySVR patientsVirologic responseC infectionHCV infection
2018
Histologic features of autoimmune hepatitis: a critical appraisal
Gurung A, Assis DN, McCarty TR, Mitchell KA, Boyer JL, Jain D. Histologic features of autoimmune hepatitis: a critical appraisal. Human Pathology 2018, 82: 51-60. PMID: 30041025, DOI: 10.1016/j.humpath.2018.07.014.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiopsyChildChild, PreschoolDatabases, FactualEmperipolesisFemaleHepatitis C, ChronicHepatitis, AutoimmuneHepatocytesHumansKupffer CellsLiverLiver CirrhosisLymphocytesMaleMiddle AgedPlasma CellsPredictive Value of TestsReproducibility of ResultsRetrospective StudiesSeverity of Illness IndexYoung AdultConceptsProminent plasma cellsAutoimmune hepatitisHistologic featuresPlasma cellsInflammatory gradePortal tractsScoring systemInitiation of therapySeverity of hepatitisDifferent control groupsChronic hepatitisHepatitis CFibrosis stageStudy groupDisease processHepatitisControl groupHyaline globulesFurther studiesPatientsTractCritical appraisalCellsGradeTypical features
2008
Colchicine-associated Ring Mitosis in Liver Biopsy and Their Clinical Implications
Kamath A, Mehal W, Jain D. Colchicine-associated Ring Mitosis in Liver Biopsy and Their Clinical Implications. Journal Of Clinical Gastroenterology 2008, 42: 1060-1062. PMID: 18391833, PMCID: PMC3730132, DOI: 10.1097/mcg.0b013e31803815b4.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyColchicineGoutGout SuppressantsHepatitis C, ChronicHepatocytesHumansLiverMaleMiddle AgedMitosisTransfusion ReactionConceptsChronic hepatitis CLiver biopsyHepatitis CColchicine toxicityMultiorgan failureLiver injuryHistopathologic manifestationsTissue injuryGastrointestinal tractMedical conditionsBiopsyClinical implicationsSalivary glandsInjuryAntimitotic activityMitosesColchicineToxicityTransfusionHistopathologicGoutYearsKidneyLiverTract
2007
Increased T-Cell Sinusoidal Lymphocytosis in Liver Biopsies in Patients With Chronic Hepatitis C and Mixed Cryoglobulinemia
Carmack S, Taddei T, Robert ME, Mistry P, Jain D. Increased T-Cell Sinusoidal Lymphocytosis in Liver Biopsies in Patients With Chronic Hepatitis C and Mixed Cryoglobulinemia. The American Journal Of Gastroenterology 2007, 103: ajg200850138. PMID: 17970837, DOI: 10.1111/j.1572-0241.2007.01603.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiopsy, NeedleCryoglobulinemiaFemaleHepatitis C, ChronicHumansLiverLymphocytosisMaleMiddle AgedT-LymphocytesViral LoadConceptsPresence of MCMixed cryoglobulinemiaLiver biopsySinusoidal lymphocytosisSinusoidal lymphocytesChronic hepatitis C patientsHepatitis C virus infectionKupffer cell countsMean fibrosis stageOngoing antigenic stimulationC virus infectionChronic hepatitis CChronic hepatitis C.Hepatitis C patientsRisk of lymphomaCD8-positive cellsNumber of CD68Low viral loadStage of fibrosisT-cell lymphocytesC patientsHepatitis CMC patientsHepatitis C.Lymphocyte count