Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli.
Jones FE, Jerry DJ, Guarino BC, Andrews GC, Stern DF. Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli. Molecular Cancer Research 1996, 7: 1031-8. PMID: 8853899.Peer-Reviewed Original ResearchConceptsDuctal branchingHRG-alphaMammary epitheliumMammary glandGrowth factorMammary epithelial responsesPrepubescent female miceTerminal end bud formationSecretory productsHRG-betaEnd bud formationGrowth factor alphaGrowth factor treatmentMammary gland developmentFemale miceFactor alphaMammary responseEpithelial responseHistological examinationLobuloalveolar developmentSystemic hormonesTGF-alphaExogenous estradiolVivo proliferationFactor treatmentHeregulin-Induced Growth Factor Receptor Signaling and Breast Carcinogenesis.
Riese D, Stern D. Heregulin-Induced Growth Factor Receptor Signaling and Breast Carcinogenesis. 1996 DOI: 10.21236/ada315700.Peer-Reviewed Original ResearchErbB family receptorsCellular signaling proteinsGrowth factor receptor signalingFamily receptorsBa/F3 cell lineCell linesEGF-like growth factorNeu differentiation factorEpidermal growth factor (EGF) familyGrowth factor familySignaling proteinsFactor familyGrowth factor alphaCellular responsesReceptor phosphorylationReceptor signalingErbB familyDistinct activitiesPairwise combinationsDifferentiation factorEGFBetacellulinHeregulinGrowth factorProtein