2023
The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events
Menez S, Wen Y, Xu L, Moledina D, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju P, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Liu K, Kaufman J, Kimmel P, Himmelfarb J, Coca S, Cantley L, Parikh C. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events. Kidney International 2023, 104: 1194-1205. PMID: 37652206, PMCID: PMC10840723, DOI: 10.1016/j.kint.2023.08.007.Peer-Reviewed Original ResearchConceptsMajor adverse kidney eventsUEGF/CrUrinary epidermal growth factorAdverse kidney eventsChronic kidney diseaseEpidermal growth factorKidney eventsKidney failureEGF expressionUrinary EGF/CrAcute Kidney Injury studyGrowth factorIschemia-reperfusion injuryProportional hazards regressionTubular healthKidney atrophyObservational cohortHospitalized participantsTubular functionClinical findingsHazards regressionKidney diseaseClinical variablesProgressive atrophyUrinary EGFEvaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19
Menez S, Coca S, Moledina D, Wen Y, Chan L, Thiessen-Philbrook H, Obeid W, Garibaldi B, Azeloglu E, Ugwuowo U, Sperati C, Arend L, Rosenberg A, Kaushal M, Jain S, Wilson F, Parikh C, Consortium T, Deng J, Atta M, Bagnasco S, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19. American Journal Of Kidney Diseases 2023, 82: 322-332.e1. PMID: 37263570, PMCID: PMC10229201, DOI: 10.1053/j.ajkd.2023.03.010.Peer-Reviewed Original ResearchConceptsSoluble tumor necrosis factor receptor 1Major adverse kidney eventsAdverse kidney eventsAdverse kidney outcomesAcute kidney injuryKidney eventsTumor necrosis factor receptor 1Necrosis factor receptor 1Plasma biomarkersKidney outcomesC-indexFactor receptor 1Hospitalized patientsCOVID-19KDIGO stage 3 acute kidney injuryDialysis-requiring acute kidney injuryStage 3 acute kidney injuryLong-term adverse health outcomesReceptor 1Long-term kidney dysfunctionAvailable blood samplesIdentification of patientsProportional hazards regressionAdverse health outcomesCOVID-19 hospitalizationLongitudinal biomarkers and kidney disease progression after acute kidney injury
Wen Y, Xu L, Melchinger I, Thiessen-Philbrook H, Moledina D, Coca S, Hsu C, Go A, Liu K, Siew E, Ikizler T, Chinchilli V, Kaufman J, Kimmel P, Himmelfarb J, Cantley L, Parikh C, Consortium T. Longitudinal biomarkers and kidney disease progression after acute kidney injury. JCI Insight 2023, 8: e167731. PMID: 36951957, PMCID: PMC10243801, DOI: 10.1172/jci.insight.167731.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAnimalsBiomarkersDisease ProgressionInflammationKidneyMiceProspective StudiesRenal Insufficiency, ChronicConceptsAcute kidney injuryIschemic reperfusion injuryKidney disease progressionKidney injuryTubular healthDisease progressionChronic kidney disease (CKD) incidenceCox proportional hazards regressionMurine acute kidney injuryKidney disease incidenceUrine KIM-1Proportional hazards regressionCKD progressionCKD transitionUrine uromodulinIncident CKDComposite outcomeKidney atrophyProspective cohortReperfusion injuryHazards regressionKIM-1Prognostic valueMCP-1Initial insult
2022
Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study
Vasquez-Rios G, Moledina D, Jia Y, McArthur E, Mansour S, Thiessen-Philbrook H, Shlipak M, Koyner J, Garg A, Parikh C, Coca S. Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study. Journal Of Cardiothoracic Surgery 2022, 17: 338. PMID: 36567329, PMCID: PMC9790121, DOI: 10.1186/s13019-022-02066-4.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Cardiovascular eventsCardiac surgeryCKD eventsCohort studyPlasma kidney injury molecule-1Chronic kidney disease (CKD) incidenceKidney disease incidenceKidney function dataPre-operative concentrationsInjury molecule-1Evaluation of patientsHigh-risk adultsLong-term outcomesHigh-risk individualsTumor necrosis factor receptorNecrosis factor receptorKidney eventsMedian followPlasma sTNFR1Hazard ratioClinical outcomesKidney biomarkersPlasma biomarkersClinical covariatesPlasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies
Coca SG, Vasquez-Rios G, Mansour SG, Moledina DG, Thiessen-Philbrook H, Wurfel MM, Bhatraju P, Himmelfarb J, Siew E, Garg AX, Hsu CY, Liu KD, Kimmel PL, Chinchilli VM, Kaufman JS, Wilson M, Banks RE, Packington R, McCole E, Kurth MJ, Richardson C, Go AS, Selby NM, Parikh CR. Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies. American Journal Of Kidney Diseases 2022, 81: 190-200. PMID: 36108888, PMCID: PMC9868060, DOI: 10.1053/j.ajkd.2022.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiomarkersHeart FailureHospitalizationHumansProspective StudiesReceptors, Tumor Necrosis FactorConceptsSoluble tumor necrosis factor receptor 1Acute kidney injuryHeart failureClinical eventsIndex hospitalizationPlasma soluble tumour necrosis factor receptor 1Soluble tumour necrosis factor receptor concentrationsBiomarker measurementsKidney disease incidenceBaseline serum samplesKidney disease progressionLate heart failureTumor necrosis factor receptor 1Association of biomarkersProportional hazards modelNecrosis factor receptor 1Magnitude of associationFactor receptor 1AKI statusIndex admissionKidney eventsKidney outcomesAKI definitionKidney injuryHospital discharge
2021
Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19
Menez S, Moledina DG, Thiessen-Philbrook H, Wilson FP, Obeid W, Simonov M, Yamamoto Y, Corona-Villalobos CP, Chang C, Garibaldi BT, Clarke W, Farhadian S, Dela Cruz C, Coca SG, Parikh CR, Investigators T, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19. American Journal Of Kidney Diseases 2021, 79: 257-267.e1. PMID: 34710516, PMCID: PMC8542781, DOI: 10.1053/j.ajkd.2021.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryBiomarkersCOVID-19CreatinineHumansLipocalin-2PrognosisProspective StudiesSARS-CoV-2ConceptsAdverse kidney outcomesNeutrophil gelatinase-associated lipocalinUrinary biomarkersBiomarker levelsKidney outcomesPrimary outcomeClinical AKIKidney injuryComposite outcomeCOVID-19KDIGO stage 3 AKIKidney injury molecule-1Cox proportional hazards regressionEpidermal growth factor levelsStage 3 AKIPrimary composite outcomeInjury molecule-1Kidney disease progressionGelatinase-associated lipocalinAdditional prognostic informationComposite outcome eventsProportional hazards regressionCOVID-19 patientsGrowth factor levelsCoronavirus disease 2019Rationale and design of the Kidney Precision Medicine Project
de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O’Toole J, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J, Project K, Knight R, Lecker S, Stillman I, Waikar S, Mcmahon G, Weins A, Short S, Hacohen N, Hoover P, Aulisio M, Cooperman L, Herlitz L, O’Toole J, Poggio E, Sedor J, Jolly S, Appelbaum P, Balderes O, Barasch J, Bomback A, Canetta P, d’Agati V, Kiryluk K, Kudose S, Mehl K, Radhakrishnan J, Weng C, Barisoni L, Alexandrov T, Ashkar T, Barwinska D, Dagher P, Dunn K, Eadon M, Ferkowicz M, Kelly K, Sutton T, Winfree S, Menez S, Parikh C, Rosenberg A, Villalobos P, Malik R, Fine D, Atta M, Trujillo J, Slack A, Rosas S, Williams M, Azeloglu E, He C, Iyengar R, Hansen J, Parikh S, Rovin B, Anderton C, Pasa-Tolic L, Velickovic D, Lukowski J, Oliver G, Ardayfio J, Bebiak J, Brown K, Campbell T, Campbell C, Hayashi L, Jefferson N, Koewler R, Roberts G, Saul J, Shpigel A, Stutzke E, Wright L, Miegs L, Pinkeney R, Sealfon R, Troyanskaya O, Tuttle K, Dobi D, Goltsev Y, Lake B, Zhang K, Joanes M, Laszik Z, Schroeder A, Sarwal M, Sigdel T, Balis U, Blanc V, He O, Hodgin J, Kretzler M, Mariani L, Menon R, Otto E, Schaub J, Steck B, Lienczewski C, Eddy S, Elder M, Hall D, Kellum J, Kruth M, Murugan R, Palevsky P, Randhawa P, Rosengart M, Sims-Lucas S, Stefanick M, Stull S, Tublin M, Alpers C, de Boer I, Dighe A, Himmelfarb J, Mcclelland R, Mooney S, Shankland S, Williams K, Blank K, Carson J, Dowd F, Drager Z, Park C, Sharma K, Zhang G, Bansal S, Venkatachalam M, Kermani A, Lee S, Lu C, Miller T, Moe O, Park H, Sambandam K, Sanchez F, Torrealba J, Robert T, Vazquez M, Wang N, Gaut J, Jain S, Vijayan A, Luciano R, Moledina D, Ugochukwu U, Wilson F, Alfano S. Rationale and design of the Kidney Precision Medicine Project. Kidney International 2021, 99: 498-510. PMID: 33637194, PMCID: PMC8330551, DOI: 10.1016/j.kint.2020.08.039.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultHumansKidneyPrecision MedicineProspective StudiesProteomicsRenal Insufficiency, ChronicConceptsAcute kidney injuryChronic kidney diseaseKidney Precision Medicine ProjectKidney biopsyKidney diseasePrecision Medicine ProjectKidney tissueMulticenter prospective cohort studyProtocol kidney biopsiesProspective cohort studyDeep clinical phenotypingPrecision medicine approachMedicine ProjectKidney injuryClinical characteristicsCohort studyClinical outcomesSubgroup analysisMorbid diseaseNovel therapiesPreventive strategiesClinical phenotypingDisease subgroupsToxic injuryPatients
2020
Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery
Menez S, Moledina DG, Garg AX, Thiessen-Philbrook H, McArthur E, Jia Y, Liu C, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Wilson FP, Coca SG, Parikh CR. Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery. Kidney International 2020, 99: 716-724. PMID: 32721447, PMCID: PMC8077034, DOI: 10.1016/j.kint.2020.06.037.Peer-Reviewed Original ResearchConceptsEstimated glomerular filtration rateChronic kidney diseaseBaseline estimated glomerular filtration rateCardiac surgeryCKD incidenceKidney diseaseBlood biomarkersN-terminal pro-B-type natriuretic peptideDevelopment of CKDPro-B-type natriuretic peptideReplication cohortAcute kidney injury groupLong-term kidney outcomesKidney injury molecule-1Acute kidney injuryPrimary composite outcomeInjury molecule-1Post-operative levelsGlomerular filtration rateTumor necrosis factor receptor 1Necrosis factor receptor 1Basic fibroblast growth factorFactor receptor 1Fibroblast growth factorAKI studiesReal-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept
Ugwuowo U, Yamamoto Y, Arora T, Saran I, Partridge C, Biswas A, Martin M, Moledina DG, Greenberg JH, Simonov M, Mansour SG, Vela R, Testani JM, Rao V, Rentfro K, Obeid W, Parikh CR, Wilson FP. Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept. American Journal Of Kidney Diseases 2020, 76: 806-814.e1. PMID: 32505812, PMCID: PMC8667815, DOI: 10.1053/j.ajkd.2020.05.003.Peer-Reviewed Original ResearchConceptsAKI alertsHospitalized adultsKidney injuryUrban tertiary care hospitalAcute kidney injurySerum creatinine levelsObservational cohort studyTertiary care hospitalSerum creatinine concentrationBeats/minElectronic health recordsAKI diagnosisCohort studyCreatinine levelsInpatient mortalitySystolic bloodFractional excretionCenter studyBlood biomarkersUnivariable associationsUrine microscopyCreatinine concentrationClinical careElevated riskUrea nitrogenAssociation Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes
Bhatraju PK, Zelnick LR, Chinchilli VM, Moledina DG, Coca SG, Parikh CR, Garg AX, Hsu CY, Go AS, Liu KD, Ikizler TA, Siew ED, Kaufman JS, Kimmel PL, Himmelfarb J, Wurfel MM. Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes. JAMA Network Open 2020, 3: e202682. PMID: 32282046, PMCID: PMC7154800, DOI: 10.1001/jamanetworkopen.2020.2682.Peer-Reviewed Original ResearchConceptsMajor adverse kidney eventsAcute kidney injuryProgressive chronic kidney diseaseChronic kidney diseaseKidney function recoverySerum creatinine concentrationKidney injuryClinical outcomesFunction recoveryKidney diseaseCreatinine concentrationHigh riskLong-term clinical outcomesAdverse kidney eventsAdjusted hazard ratioMulticenter cohort studyGlomerular filtration rateLong-term dialysisPopulation of patientsLong-term outcomesPatient risk stratificationRecognition of patientsLong-term riskAKI diagnosisAKI severity
2019
Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery
Patel DM, Thiessen-Philbrook H, Brown JR, McArthur E, Moledina DG, Mansour SG, Shlipak MG, Koyner JL, Kavsak P, Whitlock RP, Everett AD, Malenka DJ, Garg AX, Coca SG, Parikh CR. Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery. American Heart Journal 2019, 220: 253-263. PMID: 31911262, PMCID: PMC7008086, DOI: 10.1016/j.ahj.2019.11.014.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedBiomarkersBlood ProteinsCardiac Surgical ProceduresCardiovascular DiseasesCause of DeathCohort StudiesCoronary Artery BypassFemaleGalectin 3GalectinsHeart Valve Prosthesis ImplantationHumansInterleukin-1 Receptor-Like 1 ProteinMalePostoperative ComplicationsProspective StudiesVentricular RemodelingConceptsGal-3 levelsCardiovascular eventsCardiac surgerySignificant post-operative morbidityGalectin-3Gal-3 valuesPlasma soluble ST2Composite primary outcomePrimary composite outcomePost-operative morbidityCongestive heart failurePost-operative changesPotential clinical utilityRandom-effects modelPlasma sST2Soluble suppressionComposite outcomeHazard ratioProspective cohortTumorigenicity 2Heart failurePrimary outcomeMyocardial remodelingClinical covariatesClinical utilityThe Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery
Mansour SG, Zhang WR, Moledina D, Coca SG, Jia Y, Thiessen-Philbrook H, McArthur E, Inoue K, Koyner JL, Shlipak MG, Wilson FP, Garg AX, Ishibe S, Parikh CR, Consortium T. The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery. American Journal Of Kidney Diseases 2019, 74: 36-46. PMID: 30955944, PMCID: PMC6591032, DOI: 10.1053/j.ajkd.2019.01.028.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedBiomarkersCardiac Surgical ProceduresCreatinineEndpoint DeterminationFemaleHumansKidneyMaleMiddle AgedNeovascularization, PhysiologicOutcome Assessment, Health CarePostoperative ComplicationsProspective StudiesReceptors, Vascular Endothelial Growth FactorRisk AssessmentUnited StatesVascular Endothelial Growth Factor AConceptsAcute kidney injuryCardiac surgeryAKI durationKidney injuryProangiogenic markersAngiogenesis markersOutcomes of AKILong-term outcomesPlasma VEGF concentrationsTRIBE-AKI cohortAntiangiogenic markersCause mortalityPreoperative concentrationsHospital dischargeProcess of angiogenesisMarker levelsVEGFR1 levelsPGF concentrationsHigher oddsMortality riskHigh riskLower oddsVEGF concentrationsAngiogenic markersSurgery
2017
Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury
Moledina DG, Hall IE, Thiessen-Philbrook H, Reese PP, Weng FL, Schröppel B, Doshi MD, Wilson FP, Coca SG, Parikh CR. Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury. American Journal Of Kidney Diseases 2017, 70: 807-816. PMID: 28844586, PMCID: PMC5701867, DOI: 10.1053/j.ajkd.2017.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultArea Under CurveBiomarkersCohort StudiesCreatinineCross-Sectional StudiesFatty Acid-Binding ProteinsFemaleHepatitis A Virus Cellular Receptor 1HumansInterleukin-18Kidney TransplantationKidney TubulesLipocalin-2MaleMiddle AgedProspective StudiesROC CurveSeverity of Illness IndexTissue DonorsConceptsSevere acute tubular injuryAcute kidney injuryAcute tubular injuryTubular injurySCr concentrationNGAL concentrationsUrinary biomarkersDeceased donorsOrgan procurementMulticenter prospective cohortUrinary L-FABPUrinary NGAL concentrationsDeceased kidney donorsKidney injury biomarkersSerum creatinine concentrationPoor diagnostic performanceAKI casesAKI causesDonor hospitalizationKidney injuryProspective cohortSerum creatinineInjury biomarkersKidney biopsyIL-18Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease
Coca SG, Nadkarni GN, Huang Y, Moledina DG, Rao V, Zhang J, Ferket B, Crowley ST, Fried LF, Parikh CR. Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease. Journal Of The American Society Of Nephrology 2017, 28: 2786-2793. PMID: 28476763, PMCID: PMC5576932, DOI: 10.1681/asn.2016101101.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRandomized Controlled Trials as TopicReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIConceptsKidney injury molecule-1Diabetic kidney diseaseTNF receptor 1Progressive diabetic kidney diseaseRenal outcomesTNFR-2Kidney diseaseBaseline levelsAdvanced diabetic kidney diseaseIncident diabetic kidney diseaseKIM-1 levelsKidney function declineInjury molecule-1Prospective cohort studyBaseline plasma samplesBiomarkers of inflammationClinical prognostic modelDiverse pathophysiologic mechanismsType 2 diabetesCase-control studyHigher baseline levelsEGFR declineCohort studyFunction declinePathophysiologic mechanismsPlasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations
Moledina DG, Isguven S, McArthur E, Thiessen-Philbrook H, Garg AX, Shlipak M, Whitlock R, Kavsak PA, Coca SG, Parikh CR, Consortium T. Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations. The Annals Of Thoracic Surgery 2017, 104: 613-620. PMID: 28223055, PMCID: PMC5588689, DOI: 10.1016/j.athoracsur.2016.11.036.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedBiomarkersCardiac Surgical ProceduresCause of DeathChemokine CCL2FemaleFollow-Up StudiesHeart DiseasesHumansIncidenceMaleOdds RatioOntarioPostoperative ComplicationsPreoperative PeriodPrognosisProspective StudiesRisk AssessmentRisk FactorsSurvival RateUnited StatesConceptsAcute kidney injuryMCP-1 levelsRisk of deathCardiac operationsChemotactic protein-1Highest tertileKidney injuryMCP-1Plasma MCP-1 levelsSevere acute kidney injuryMonocyte chemotactic protein-1High-risk patientsIschemia-reperfusion injuryPlasma MCP-1Protein 1AKI outcomesAKI riskAdjusted riskObservational cohortPrevention strategiesPromising biomarkerBiomarker endpointsTertileInjuryTranslational research
2016
Application of new acute kidney injury biomarkers in human randomized controlled trials
Parikh CR, Moledina DG, Coca SG, Thiessen-Philbrook HR, Garg AX. Application of new acute kidney injury biomarkers in human randomized controlled trials. Kidney International 2016, 89: 1372-1379. PMID: 27165835, PMCID: PMC4869991, DOI: 10.1016/j.kint.2016.02.027.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAKI biomarkersKidney injuryClinical trialsNew biomarkersEarly acute kidney injuryObserved relative risk reductionPostoperative acute kidney injuryAcute kidney injury biomarkersHypothetical trialKidney injury progressionMulti-country trialAcute tubular necrosisCardiopulmonary bypass timeClinical risk factorsKidney injury biomarkersProportion of patientsProspective cohort studyKidney injury markersRelative risk reductionAKI progressionAKI trialsBypass timeCohort studyInjury markers
2015
Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study
Moledina DG, Parikh CR, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Devarajan P, Shlipak MG, Coca SG, . Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study. PLOS ONE 2015, 10: e0129619. PMID: 26053382, PMCID: PMC4460181, DOI: 10.1371/journal.pone.0129619.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAgedAged, 80 and overBiomarkersCardiac Surgical ProceduresCause of DeathCohort StudiesCreatinineFemaleFollow-Up StudiesHumansKidney Function TestsLipocalin-2LipocalinsMaleMiddle AgedMortalityPerioperative PeriodProspective StudiesProto-Oncogene ProteinsRisk FactorsTime FactorsConceptsPlasma neutrophil gelatinase-associated lipocalinProspective observational cohort studyLong-term mortalityObservational cohort studySerum creatinineCardiac surgeryCohort studyIndependent associationPlasma neutrophil gelatinase associated lipocalin (NGAL) levelsNeutrophil Gelatinase-Associated Lipocalin LevelsShort-term adverse outcomesNeutrophil gelatinase-associated lipocalinAcute kidney injuryPre-operative variablesIntra-operative variablesGelatinase-associated lipocalinGlomerular filtration ratePre-operative levelsPeri-operative changesPost-operative dayTRIBE-AKI cohortLipocalin levelsCause mortalityKidney injuryNGAL levels
2013
A Pilot Trial of a Computerized Renal Template Note to Improve Resident Knowledge and Documentation of Kidney Disease
Shirazian S, Wang R, Moledina D, Liberman V, Zeidan J, Strand D, Mattana J. A Pilot Trial of a Computerized Renal Template Note to Improve Resident Knowledge and Documentation of Kidney Disease. Applied Clinical Informatics 2013, 04: 528-540. PMID: 24454580, PMCID: PMC3885913, DOI: 10.4338/aci-2013-07-ra-0048.Peer-Reviewed Original ResearchConceptsAcute kidney injuryEarly-stage CKDKidney diseaseStage CKDEarly recognitionDocumentation of AKIResidents' knowledgeChronic kidney disease categoryFirst-year medical residentsAdvanced CKD stagesResident progress notesTreatment of CKDNon-significant improvementYear medical residentsCKD categoriesCKD stageKidney injuryClinical decision supportProspective studyCKD classificationInpatient encountersPhysician recognitionPilot trialPhysician notesDisease categories