Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats
Hamurtekin E, Bagdas D, Gurun M. Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats. Neuroscience Letters 2007, 420: 116-121. PMID: 17531379, DOI: 10.1016/j.neulet.2007.04.058.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdrenergic alpha-AntagonistsAnalgesicsAnimalsBrainCytidine Diphosphate CholineDisease Models, AnimalEfferent PathwaysGABA AntagonistsInjections, IntraventricularMaleNarcotic AntagonistsNociceptorsPainPain MeasurementPain ThresholdRatsRats, Sprague-DawleyReceptors, Adrenergic, alphaReceptors, GABAReceptors, GABA-BReceptors, OpioidReceptors, SerotoninSerotonin AntagonistsConceptsAcute pain modelsMechanical paw pressure testThermal paw withdrawal testPaw pressure testPaw withdrawal testAntinociceptive effectPain modelSupraspinal opioidsSerotonergic receptorsAlpha-1 adrenergic receptor antagonist prazosinCDP-cholineWithdrawal testOpioid receptor antagonist naloxoneAdrenergic receptor antagonist prazosinAdrenergic receptor antagonist yohimbineCytidine-5′-diphosphate cholineDifferent pain modelsExerts antinociceptive effectsDose-dependent antinociceptionReceptor antagonist yohimbineReceptor antagonist prazosinReceptor-mediated mechanismMethysergide pretreatmentAntagonist yohimbineAntagonist prazosin