2019
Neuropathic insult increases the responsiveness to acetic acid in mice.
Gurdap C, Markwalter P, Neddenriep B, Bagdas D, Damaj M. Neuropathic insult increases the responsiveness to acetic acid in mice. Behavioural Pharmacology 2019, 30: 534-537. PMID: 31033524, PMCID: PMC6684379, DOI: 10.1097/fbp.0000000000000486.Peer-Reviewed Original ResearchConceptsChronic constriction injuryChronic neuropathic painNeuropathic painPlace aversionAcute visceral painVehicle-treated micePeripheral nerve injuryPlace aversion (CPA) testPaclitaxel-treated animalsMillions of patientsCCI miceConstriction injuryVisceral painCCI animalsSham miceAcute painNerve injuryControl miceSciatic nerveNeuropathic insultMale miceNociceptive modelsPaclitaxel treatmentPainPlace conditioning
2018
Effect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice
Bagdas D, Meade J, Alkhlaif Y, Muldoon P, Carroll F, Damaj M. Effect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice. European Journal Of Pain 2018, 22: 1419-1427. PMID: 29633429, PMCID: PMC6179949, DOI: 10.1002/ejp.1231.Peer-Reviewed Original ResearchEffects of nicotineVisceral painΑ7 nAChRsPlace aversionIntraperitoneal acetic acid administrationAcetic acid administrationAllosteric modulationΑ7-nAChR activationDose-dependent reductionNAChR agonist nicotineNeurobiology of painDose-dependent mannerAntinociceptive effectAcid administrationPeripheral mechanismsAntinociceptive propertiesNAChR activationNicotine effectsNicotinic antagonistsNovel analgesicsSystemic administrationReceptor modulatorsAgonist nicotineNAChR agonistsPain
2016
Expression and Pharmacological Modulation of Visceral Pain‐Induced Conditioned Place Aversion in Mice
AlSharari S, Bagdas D, Muldoon P, Carroll I, Negus S, Damaj I. Expression and Pharmacological Modulation of Visceral Pain‐Induced Conditioned Place Aversion in Mice. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.928.6.Peer-Reviewed Original ResearchAnalgesic drugsPlace aversionK-opioid receptor agonistsOpioid receptor agonist morphineConditioned Place AversionNovel analgesic drugsReceptor agonist morphineAcetic acid injectionNegative affective componentVisceral painNonsteroidal anti-inflammatory drug ketoprofenAgonist morphineNociceptive behaviorPain signsReceptor agonistAnti-inflammatory drug ketoprofenPharmacological modulationPainAcid injectionMorphineMiceReversal abilitySensory componentDrugsNumber of stretches
2015
Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice
Bagdas D, Muldoon P, AlSharari S, Carroll F, Negus S, Damaj M. Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice. Neuropharmacology 2015, 102: 236-243. PMID: 26639043, PMCID: PMC5574195, DOI: 10.1016/j.neuropharm.2015.11.024.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-IsomerAnalgesics, OpioidAnimalsAnti-Inflammatory Agents, Non-SteroidalAvoidance LearningBehavior, AnimalKetoprofenMaleMiceMice, Inbred ICRMorphinePiperidinesReceptors, Opioid, kappaReceptors, Opioid, muTetrahydroisoquinolinesVisceral PainConceptsMu-opioid receptor agonist morphinePlace aversionOpioid receptor agonist morphineReceptor agonist morphineMale ICR micePlace aversion (CPA) testPreclinical mouse modelsCandidate analgesicsNonsteroidal anti-inflammatory drug ketoprofenAgonist morphineOpioid agonistsICR miceIntraperitoneal administrationAnti-inflammatory drug ketoprofenPreclinical studiesMouse modelPharmacological modulationAnimal modelsMorphinePainReversal abilityAversion testAversive behaviorMiceBiological mechanisms