2017
Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain
Bagdas D, Ergun D, Jackson A, Toma W, Schulte M, Damaj M. Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain. European Journal Of Pain 2017, 22: 84-93. PMID: 28809075, PMCID: PMC9829446, DOI: 10.1002/ejp.1092.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsChronic neuropathic painNeuropathic painΑ4β2 nAChRsNicotinic acetylcholine receptorsAllosteric modulationAcetylcholine receptorsAntagonist dihydro-β-erythroidineNeuronal nicotinic acetylcholine receptorsChronic constriction injuryEndogenous cholinergic toneNicotine-evoked responsesAnimal pain modelsNicotine-induced antinociceptionDihydro-β-erythroidineMediation of painAlternative treatment strategiesBehavior doseConstriction injuryAntiallodynic effectPain modelPain modulationCholinergic tonePain behaviorAntinociceptive properties
2015
Effects of GAT107, an Allosteric Agonist and Positive Modulator of α7 Nicotinic Acetylcholine Receptors, on Chronic Inflammatory and Neuropathic Pain in Mice
Bagdas D, Wilkerson J, Lichtman A, Thakur G, Damaj M. Effects of GAT107, an Allosteric Agonist and Positive Modulator of α7 Nicotinic Acetylcholine Receptors, on Chronic Inflammatory and Neuropathic Pain in Mice. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.616.12.Peer-Reviewed Original ResearchPositive allosteric modulatorsΑ7 nicotinic acetylcholine receptorNeuropathic painNicotinic acetylcholine receptorsAntinociceptive effectAgo-PAMChronic constriction injury-induced neuropathic painAcetylcholine receptorsAllosteric agonistInjury-induced neuropathic painPain-induced aversionAcetic acid injectionNew pharmacological approachesPlace aversion (CPA) testNovel therapeutic approachesAcute thermal stimulusMassey Cancer CenterComplete Freud'sInflammatory painChronic inflammatoryFormalin testPain modulationPain behaviorCancer CenterSystemic administration