2020
Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
Bagdas D, Gul Z, Meade JA, Cam B, Cinkilic N, Gurun MS. Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation. Current Neuropharmacology 2020, 18: 216-228. PMID: 31631820, PMCID: PMC7327949, DOI: 10.2174/1570159x17666191021111809.Peer-Reviewed Original ResearchConceptsLiterature searchElectronic literature searchDifferent pathological situationsChlorogenic acidPharmacologic overviewNeuropathic painPain managementChronic painInflammatory insultPreventive roleAnimal modelsInflammationPotent antioxidantCertain foodsOxidative stressEthnopharmacological reportsPutative mechanismsDietary plantsAntioxidant defenseNatural phenolic compoundsPathological situationsPainMedicinal herbsOriginal articlesPhenolic compounds
2019
Neuropathic insult increases the responsiveness to acetic acid in mice.
Gurdap C, Markwalter P, Neddenriep B, Bagdas D, Damaj M. Neuropathic insult increases the responsiveness to acetic acid in mice. Behavioural Pharmacology 2019, 30: 534-537. PMID: 31033524, PMCID: PMC6684379, DOI: 10.1097/fbp.0000000000000486.Peer-Reviewed Original ResearchConceptsChronic constriction injuryChronic neuropathic painNeuropathic painPlace aversionAcute visceral painVehicle-treated micePeripheral nerve injuryPlace aversion (CPA) testPaclitaxel-treated animalsMillions of patientsCCI miceConstriction injuryVisceral painCCI animalsSham miceAcute painNerve injuryControl miceSciatic nerveNeuropathic insultMale miceNociceptive modelsPaclitaxel treatmentPainPlace conditioningChapter 33 Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain
Bagdas D, Kyte S, Toma W, Gurun M, Damaj M. Chapter 33 Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain. 2019, 259-266. DOI: 10.1016/b978-0-12-813035-3.00033-2.Peer-Reviewed Original ResearchNicotinic acetylcholine receptorsAcetylcholine receptorsNAChR ligandsTreatment of painRecent animal studiesNarrow therapeutic windowPeripheral nervous systemPositive allosteric modulatorsAnalgesic efficacyPain managementChronic painNeuropathic conditionsImmune cellsNovel analgesicsTherapeutic windowAnimal modelsAnimal studiesHuman studiesNervous systemNicotinic agentsAllosteric modulatorsTherapeutic potentialPainPromising agentSilent agonist
2018
Effect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice
Bagdas D, Meade J, Alkhlaif Y, Muldoon P, Carroll F, Damaj M. Effect of nicotine and alpha‐7 nicotinic modulators on visceral pain‐induced conditioned place aversion in mice. European Journal Of Pain 2018, 22: 1419-1427. PMID: 29633429, PMCID: PMC6179949, DOI: 10.1002/ejp.1231.Peer-Reviewed Original ResearchEffects of nicotineVisceral painΑ7 nAChRsPlace aversionIntraperitoneal acetic acid administrationAcetic acid administrationAllosteric modulationΑ7-nAChR activationDose-dependent reductionNAChR agonist nicotineNeurobiology of painDose-dependent mannerAntinociceptive effectAcid administrationPeripheral mechanismsAntinociceptive propertiesNAChR activationNicotine effectsNicotinic antagonistsNovel analgesicsSystemic administrationReceptor modulatorsAgonist nicotineNAChR agonistsPainNew Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs
Bagdas D, Gurun M, Flood P, Papke R, Damaj M. New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs. Current Neuropharmacology 2018, 16: 415-425. PMID: 28820052, PMCID: PMC6018191, DOI: 10.2174/1570159x15666170818102108.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptorsΑ7 nAChRsAcetylcholine receptorsNeuronal nicotinic acetylcholine receptorsPerspective of painChronic pain conditionsTreatment of painRecent animal studiesPain controlPain conditionsSide effectsAnimal studiesTherapeutic targetingPainReceptor typesNAChRsReceptorsInflammationSelective ligandsΑ7Latest findingsTreatmentRecent insightsReviewNicotineCurcumin acts as a positive allosteric modulator of α7-nicotinic acetylcholine receptors and reverses nociception in mouse models of inflammatory pain
El Nebrisi E, Bagdas D, Toma W, Al Samri H, Brodzik A, Alkhlaif Y, Yang K, Howarth F, Damaj I, Oz M. Curcumin acts as a positive allosteric modulator of α7-nicotinic acetylcholine receptors and reverses nociception in mouse models of inflammatory pain. Journal Of Pharmacology And Experimental Therapeutics 2018, 365: jpet.117.245068. PMID: 29339457, PMCID: PMC7947331, DOI: 10.1124/jpet.117.245068.Peer-Reviewed Original ResearchConceptsEffect of curcuminPositive allosteric modulatorsMouse modelVisceral painAntinociceptive effectNACh receptorsAcetylcholine receptorsAllosteric modulatorsΑ7 nicotinic acetylcholine receptorVisceral pain modelHuman nicotinic acetylcholine receptorNicotinic acetylcholine receptorsInflammatory painPain modelNociceptive behaviorReceptor agonistSignificant potentiationDependent ClLocomotor activityACh concentrationPainNociceptionReceptorsTonicG proteins
2016
Expression and Pharmacological Modulation of Visceral Pain‐Induced Conditioned Place Aversion in Mice
AlSharari S, Bagdas D, Muldoon P, Carroll I, Negus S, Damaj I. Expression and Pharmacological Modulation of Visceral Pain‐Induced Conditioned Place Aversion in Mice. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.928.6.Peer-Reviewed Original ResearchAnalgesic drugsPlace aversionK-opioid receptor agonistsOpioid receptor agonist morphineConditioned Place AversionNovel analgesic drugsReceptor agonist morphineAcetic acid injectionNegative affective componentVisceral painNonsteroidal anti-inflammatory drug ketoprofenAgonist morphineNociceptive behaviorPain signsReceptor agonistAnti-inflammatory drug ketoprofenPharmacological modulationPainAcid injectionMorphineMiceReversal abilitySensory componentDrugsNumber of stretches
2015
Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice
Bagdas D, Muldoon P, AlSharari S, Carroll F, Negus S, Damaj M. Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice. Neuropharmacology 2015, 102: 236-243. PMID: 26639043, PMCID: PMC5574195, DOI: 10.1016/j.neuropharm.2015.11.024.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-IsomerAnalgesics, OpioidAnimalsAnti-Inflammatory Agents, Non-SteroidalAvoidance LearningBehavior, AnimalKetoprofenMaleMiceMice, Inbred ICRMorphinePiperidinesReceptors, Opioid, kappaReceptors, Opioid, muTetrahydroisoquinolinesVisceral PainConceptsMu-opioid receptor agonist morphinePlace aversionOpioid receptor agonist morphineReceptor agonist morphineMale ICR micePlace aversion (CPA) testPreclinical mouse modelsCandidate analgesicsNonsteroidal anti-inflammatory drug ketoprofenAgonist morphineOpioid agonistsICR miceIntraperitoneal administrationAnti-inflammatory drug ketoprofenPreclinical studiesMouse modelPharmacological modulationAnimal modelsMorphinePainReversal abilityAversion testAversive behaviorMiceBiological mechanismsThe role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain
Bagdas D, AlSharari S, Freitas K, Tracy M, Damaj M. The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain. Biochemical Pharmacology 2015, 97: 590-600. PMID: 25931144, PMCID: PMC4600420, DOI: 10.1016/j.bcp.2015.04.013.Peer-Reviewed Original ResearchConceptsΑ5-KO miceΑ5 nAChRInflammatory painFormalin testPain modelChronic painMouse modelTumor necrosis factor-alpha levelsLong-term inflammatory painNecrosis factor-alpha levelsPaw-licking timeTonic inflammatory painChronic pain modelsDevelopment of hyperalgesiaInflammatory pain modelWild-type miceNicotinic acetylcholine receptorsAllodynic responsesMechanical allodyniaNicotine reversalCFA injectionNeuropathic painAntinociceptive effectNociceptive behaviorPain
2014
The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor
Papke R, Bagdas D, Kulkarni A, Gould T, AlSharari S, Thakur G, Damaj M. The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 2014, 91: 34-42. PMID: 25497451, PMCID: PMC4312719, DOI: 10.1016/j.neuropharm.2014.12.002.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsChronic painAntinociceptive activityΑ7 nicotinic acetylcholine receptorAnalgesic-like propertiesPain-induced aversionNerve injury modelAcute thermal painNon-neuronal cellsNicotinic acetylcholine receptorsImportant affective componentIon channelsNeuropathic painPain modelNociceptive behaviorInflammatory diseasesInjury modelNS6740Α7 nAChRsΑ7 receptorsThermal painPainAcetylcholine receptorsChannel activatorNeurological disordersAntinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy
Bagdas D, Ozboluk H, Cinkilic N, Gurun M. Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy. Journal Of Medicinal Food 2014, 17: 730-732. PMID: 24611441, DOI: 10.1089/jmf.2013.2966.Peer-Reviewed Original ResearchConceptsDiabetic neuropathic painAntinociceptive effectNeuropathic painChronic treatmentPainful diabetic neuropathyPossible antinociceptive effectSignificant antinociceptive effectChlorogenic acid treatmentChlorogenic acidDiabetic neuropathyNondiabetic ratsDiabetic ratsSingle doseAntinociceptive potentialRatsBeneficial effectsPainTreatmentPresent studyNeuropathyStreptozotocinHyperglycemiaDiabetesDose
2012
Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain
Bagdas D, Cinkilic N, Ozboluk H, Ozyigit M, Gurun M. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. Journal Of Natural Medicines 2012, 67: 698-704. PMID: 23203628, DOI: 10.1007/s11418-012-0726-z.Peer-Reviewed Original ResearchConceptsChronic constrictive nerve injuryNeuropathic painAntihyperalgesic activityPeripheral neuropathic pain modelExperimental neuropathic painNeuropathic pain modelRota-rod testNovel potential therapeutic optionPotential therapeutic optionStrong therapeutic effectLatency of ratsChlorogenic acidAntihyperalgesic effectMechanical hyperalgesiaNerve injuryPain modelChronic administrationInflammatory cascadeTherapeutic optionsHistopathological changesInflammatory processTherapeutic effectAnalgesic activityPainNervous system